Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2

PloS One
Sandro Silva-GomesMaria Salomé Gomes

Abstract

Important for both host and pathogen survivals, iron is a key factor in determining the outcome of an infectious process. Iron with-holding, including sequestration inside tissue macrophages, is considered an important strategy to fight infection. However, for intra-macrophagic pathogens, such as Mycobacterium avium, host defence may depend on intracellular iron sequestration mechanisms. Ferritin, the major intracellular iron storage protein, plays a critical role in this process. In the current study, we studied ferritin expression in mouse bone marrow-derived macrophages upon infection with M. avium. We found that H-ferritin is selectively increased in infected macrophages, through an up-regulation of gene transcription. This increase was mediated by the engagement of Toll like receptor-2, and was independent of TNF-alpha or nitric oxide production. The formation of H-rich ferritin proteins and the consequent iron sequestration may be an important part of the panoply of antimicrobial mechanisms of macrophages.

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Citations

Nov 7, 2019·Current Pharmaceutical Design·Joanna Giemza-StokłosaPrzemysław J Kotyla
Sep 14, 2018·Science Translational Medicine·Yun-Ruei KaoBritta Will
Apr 25, 2020·Microorganisms·Ana C MoreiraMaria Salomé Gomes
Sep 12, 2018·Pharmaceuticals·Ana Cordeiro GomesMaria Salomé Gomes
Feb 23, 2020·Scientific Reports·Gonçalo MesquitaMaria Salomé Gomes
May 22, 2019·Pharmaceuticals·Rafiou Agoro, Catherine Mura
Sep 29, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Cordeiro GomesMaria Salomé Gomes
Feb 25, 2020·Free Radical Biology & Medicine·Andrew J GhioMichael C Madden
Aug 14, 2019·Chemical Research in Toxicology·Andrew J GhioStephen P Kantrow

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Methods Mentioned

BETA
ELISA
protein assay

Software Mentioned

REST
ImageQuant

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