Mycobacterium avium ssp. hominissuis biofilm is composed of distinct phenotypes and influenced by the presence of antimicrobials.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
M McNabeL E Bermudez

Abstract

Mycobacterium avium ssp. hominissuis, hereafter referred to as M. avium, forms biofilm, a property that, in mice, is associated with lung infection via aerosol. As M. avium might co-inhabit the respiratory tract with other pathogens, treatment of the co-pathogen-associated infections, such as in bronchiectasis, would expose M. avium to therapeutic compounds that may have their origin in other organisms sharing the natural environments. Incubation of M. avium with two compounds produced by environmental organisms, streptomycin and tetracycline, in vitro at subinhibitory concentrations increased biofilm formation in a number of M. avium strains, although exposure to ampicillin, moxifloxacin, rifampin and trimethoprim-sulphamethoxazole had no effect on biofilm formation. No selection of genotypically resistant clones was observed. Although incubation of bacteria in the presence of streptomycin upregulates the expression of biofilm-associated genes, the response to the antibiotics had no association with the expression of a regulator (LysR) linked to the formation of biofilm in M. avium. Biofilms are composed of planktonic and sessile bacteria. Whereas planktonic M. avium is susceptible to clarithromycin and ethambutol (clinically ...Continue Reading

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Citations

Nov 21, 2013·Pulmonary Pharmacology & Therapeutics·M CataldiO Piazza
Mar 1, 2015·Journal of Global Antimicrobial Resistance·Maborwa T MothibaMoloko C Cholo
Oct 31, 2012·Expert Review of Anti-infective Therapy·Mohammad S IslamAnil K Ojha
Jun 2, 2020·Frontiers in Immunology·Nastaran Mues, Hong Wei Chu
Apr 4, 2021·International Journal of Molecular Sciences·Min-Kyoung Shin, Sung Jae Shin
Jun 25, 2015·Microbiology Spectrum·Jacobs P Richards, Anil K Ojha
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Reza MirnejadDavood Darban-Sarokhalil

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