Mycobacterium avium subspecies paratuberculosis is not associated with type-2 diabetes mellitus.

Annals of Clinical Microbiology and Antimicrobials
Valentina RosuLeonardo A Sechi

Abstract

The role of pathogenic mycobacteria in diabetes has been a focus of speculation since a decade without any meaningful insights into the mechanism of diabetes causation vis a vis mycobacterial factors. Two of our studies based on PCR identification of mycobacterial DNA and detection of antibodies specific to the recombinant antigens and whole cell lysates of the Mycobacterium avium subsp. paratuberculosis (MAP) shown a clear association of MAP with the presence of type 1 diabetes mellitus (T1DM). In this study, we sought to investigate if or not type 2 diabetes (T2DM) patients harbour humoral responses to MAP. Using three different MAP antigen preparations, humoral antibody profiles were estimated for 57 T2DM patients and 57 healthy controls. Statistical analysis was performed with the Chi-square test with Yates' corrections. We observed insignificant levels of humoral antibodies against recombinant heparin binding haemagglutinin (HbHA), glycosyl transferase (Gsd) and MAP whole cell lysate in the blood of subjects with T2DM as compared to healthy controls. We found no obvious association of MAP with the incidence of T2DM in Sardinian patients.

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Citations

Dec 15, 2010·Autoimmune Diseases·C Thomas Dow, Jay L E Ellingson
Jun 15, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Andrea CossuLeonardo Antonio Sechi
Mar 20, 2015·Frontiers in Immunology·Leonardo A Sechi, Coad Thomas Dow
Oct 20, 2019·Microorganisms·Coad Thomas Dow, Leonardo A Sechi

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