Mycobacterium bovis strain bacillus Calmette-Guérin-induced liver granulomas contain a diverse TCR repertoire, but a monoclonal T cell population is sufficient for protective granuloma formation

The Journal of Immunology : Official Journal of the American Association of Immunologists
Laura H HoganMatyas Sandor

Abstract

Granuloma formation is a form of delayed-type hypersensitivity requiring CD4(+) T cells. Granulomas control the growth and dissemination of pathogens, preventing host inflammation from harming surrounding tissues. Using a murine model of Mycobacterium bovis strain bacillus Calmette-Guérin (BCG) infection we studied the extent of T cell heterogeneity present in liver granulomas. We demonstrate that the TCR repertoire of granuloma-infiltrating T cells is very diverse even at the single-granuloma level, suggesting that before granuloma closure, a large number of different T cells are recruited to the lesion. At the same time, the TCR repertoire is selected, because AND TCR transgenic T cells (Valpha11/Vbeta3 anti-pigeon cytochrome c) are preferentially excluded from granulomas of BCG-infected AND mice, and cells expressing secondary endemic Vbeta-chains are enriched among AND cells homing to granulomas. Next, we addressed whether TCR heterogeneity is required for effective granuloma formation. We infected 5CC7/recombinase-activating gene 2(-/-) mice with recombinant BCG that express pigeon cytochrome c peptide in a mycobacterial 19-kDa bacterial surface lipoprotein. A CD4(+) T cell with a single specificity in the absence of CD8(+...Continue Reading

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Citations

Jul 20, 2012·Clinical & Developmental Immunology·Mayra Silva MirandaFrederic Altare
Oct 31, 2015·Scientific Reports·Jeffrey S HardingMatyas Sandor
Nov 19, 2011·European Journal of Microbiology & Immunology·H A SchreiberM Sandor
Sep 14, 2010·Memórias do Instituto Oswaldo Cruz·Tânia Regina Marques da SilvaPatrícia Sampaio Tavares Veras
Apr 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Frank HeutsMartin E Rottenberg
Nov 7, 2006·Bulletin of Mathematical Biology·Christina WarrenderFrederick Koster
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erika HeningerMatyas Sandor
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dominic O CoMatyas Sandor
Mar 25, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·JangEun LeeZsuzsanna Fabry
Sep 14, 2011·The Journal of Clinical Investigation·Heidi A SchreiberMatyas Sandor
Nov 19, 2011·FEMS Immunology and Medical Microbiology·Lisette M CarrithersMichael D Carrithers
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·JangEun LeeZsuzsanna Fabry
Jun 3, 2021·Journal of Fungi·Rebecca A WardJatin M Vyas
Jun 8, 2021·Biologia Futura·Melinda HerbathMatyas Sandor

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