Mycobacterium fortuitum glycolipids for the serodiagnosis of pulmonary tuberculosis

American Journal of Respiratory and Critical Care Medicine
L EscamillaL M López-Marín

Abstract

Glycolipids belonging to the family of acylated trehaloses were isolated from Mycobacterium fortuitum, a rapidly growing mycobacterial species, and tested in the serologic diagnosis of human pulmonary tuberculosis by enzyme-linked immunosorbent assay. Di- and tri-O-acylated trehaloses from M. fortuitum reacted with serum antibodies of patients with pulmonary tuberculosis at higher titers than did with sera from healthy donors. With both glycolipids, the sensitivity of the test was above 0.80 at a chosen specificity of 0.98. Individuals with treated tuberculosis showed lower antibody titers compared with their initial reactivities. These data show that M. fortuitum could be used as a surrogate source of antigens for tuberculosis serodiagnosis.

Citations

Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·R SaavedraL M López-Marín
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·E D ChanW E Hahn
Jun 7, 2011·Journal of Microbiological Methods·Henriette StavriPatrick J Brennan
Apr 3, 2007·Archivos de bronconeumología·José Prisco Palma-Nicolás, Virgilio Bocanegra-García
Nov 23, 2005·Microbes and Infection·Rafael SaavedraLuz M López-Marín
Oct 19, 2007·FEMS Immunology and Medical Microbiology·Raj Kumar Verma, Amita Jain
May 3, 2003·FEMS Immunology and Medical Microbiology·Luz M López-MarínMario César Salinas-Carmona
Jul 20, 2007·Scandinavian Journal of Immunology·F AbebeG Bjune
Nov 4, 2009·Expert Review of Anti-infective Therapy·Faten A Al-Zamel
Mar 9, 2005·Clinical and Diagnostic Laboratory Immunology·R P TiwariPrakash S Bisen
Nov 25, 2004·The Biochemical Journal·Goar GevorkianLuz M López-Marín
Mar 25, 2020·Biomedical Optics Express·Mildred S Cano-VelázquezJuan Hernández-Cordero

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