PMID: 11319391Apr 25, 2001Paper

Mycobacterium kansasii skin infection at insulin injection sites

Annales de dermatologie et de vénéréologie
E Domergue Thân TrongB Crickx

Abstract

Insulin injection sites rarely become infected. We report a case of Mycobacterium kansasii infection at the sites of insulin injection. An 84-year-old woman with insulin-dependent diabetes consulted for lesions on the anterior aspect of the thighs. She had papulonodules at the sites of insulin injection. These lesions progressed to hard fibrinonecrotic ulcerations with a raised erythematous border. There were no enlarged nodes locally. Laboratory tests were normal. Bacteriological samples were negative at direct examination. Histology was not specific. The biopsy cultures finally found an atypical mycobacteria, Mycobacterium kansasii. The clinical course was favorable with clarithromycin alone. Only 35 cases of Mycobacterium kansasii skin infections have been reported in the literature. This is the first case observed in a diabetic subject and the first treated with clarithromycin alone. This case illustrates the potential, though exceptional, risk of insulin bottle contamination by an environmental germ.

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