Mycobacterium leprae-induced demyelination: a model for early nerve degeneration

Current Opinion in Immunology
Anura Rambukkana

Abstract

The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.

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Citations

Apr 15, 2006·Clinical Microbiology Reviews·D M ScollardD L Williams
Jan 10, 2008·Neuro-degenerative Diseases·B FrickerF René
Mar 13, 2014·ILAR Journal·Richard W TrumanAnura Rambukkana
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Nov 21, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gigi J Ebenezer, David M Scollard

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