PMID: 108474Feb 1, 1979

Mycobacterium scrofulaceum infection in Erythrocebus patas monkeys

Laboratory Animal Science
D M Renquist, S Potkay


Mycobacterium scrofulaceum was cultured from two of seven tuberculin reactors in a group of 12 Erythrocebus patas monkeys. One monkey reacted atypically to 0.1 ml of 2.5 mg veterinary tuberculin after having shown no reaction to four previous tests administered at 2-week intervals. The reaction consisted of edema with no induration or erythema at 24 hours and was completely dissipated at 36 hours. Responses to additional tests using veterinary tuberculin (2.5 mg) and Mycobacterium bovis purified protein derivative (1.1 mg) ranged from negative to slightly edematous. Radiographs were suggestive of pulmonary tuberculosis. Extensive granulomas were observed in the lungs, liver and spleen at necropsy. Mycobacterium scrofulaceum was isolated from lung and liver granulomas in this animal and from lung granulomas in another. The atypical skin hypersensitivity and organism isolation from multiple organs suggested Mycobacterium scrofulaceum as the etiologic agent in these animals. Reactions of six other Erythrocebus patas to veterinary tuberculin (2.5 mg) ranged from edematous to indurated.

Related Concepts

Erythrocebus patas
Monkey Diseases
Mycobacterium Infections
Atypical Mycobacterial Infection, Disseminated
Tuberculin Test

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.