Mycobacterium tuberculosis can gain access to adipose depots of mice infected via the intra-nasal route and to lungs of mice with an infected subcutaneous fat implant

Microbial Pathogenesis
Pooja AgarwalManju Y Krishnan

Abstract

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis has the remarkable ability to persist as non-replicating forms in the host. These persisters are tolerant to drugs targeting actively replicating bacilli and hence are responsible for the need of an extended duration of anti-tubercular therapy. The anatomical locations and cell types housing Mtb persisters are being investigated in the recent times. Adipose tissue and the adipocytes are proposed niches of Mtb persisters. In the present study, we carried out experiments in the immunocompetent Swiss mice to see the dissemination of Mtb from lungs to adipose tissue and vice versa. Mice infected intra-nasally with ∼ 10(6), 10(4) or 10(2) bacilli harboured Mtb in various adipose depots distal to the lungs such as the visceral, subcutaneous and peri-renal depots. The dissemination was minimal at two weeks post-infection, as evident from culture negative adipose tissue samples. But at seven weeks post-infection, viable Mtb could be detected in 78%, 66% and 66% of the samples from high, moderate and low dose-infection groups respectively. In a separate experiment, Mtb-infected pre-adipocytes were implanted subcutaneously to un-infected mice. At five weeks post-implan...Continue Reading

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Citations

May 10, 2017·Future Microbiology·Haipeng Liu, Baoxue Ge
Feb 19, 2019·Microbiology·Soma MandalTanya Parish
May 26, 2020·Expert Review of Anti-infective Therapy·George PrayGod
Apr 18, 2019·MBio·Janeesh Plakkal AyyappanJyothi F Nagajyothi
Jun 8, 2018·Frontiers in Microbiology·Mohlopheni J MarakalalaSiamon Gordon
Jun 2, 2017·Frontiers in Cellular and Infection Microbiology·Fériel BouzidStéphane Canaan

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