Mycobacterium tuberculosis exposure of livestock in a German dairy farm: implications for intra vitam diagnosis of bovine tuberculosis in an officially tuberculosis-free country

Epidemiology and Infection
T EisenbergC Menge

Abstract

Germany has been an officially bovine tuberculosis (bTB)-free (OTF) country since 1996. Gradually rising numbers of bTB herd incidents due to Mycobacterium bovis and M. caprae in North-Western and Southern Germany during the last few years prompted the competent authorities to conduct a nationwide bTB survey in 2013/2014. This led to the detection of a dairy herd in which as many as 55 cattle reacted positively to consecutive intra vitam testing. Test-positive animals lacked visible lesions indicative of bTB at necropsy. Extensive mycobacterial culturing as well as molecular testing of samples from 11 tissues for members of the M. tuberculosis complex (MTC) yielded negative results throughout. However, caseous lymphadenitis of Ln. mandibularis accessorius was observed during meat inspection of a fattening pig from the same farm at regular slaughter at that time. Respective tissue samples tested MTC positive by polymerase chain reaction, and M. tuberculosis T1 family were identified by spoligotyping. Four human reactors within the farmer's family were also found to be immunoreactive. As exposure of livestock to M. tuberculosis is not generally considered, its impact may result in regulatory and practical difficulties when using ...Continue Reading

References

Jan 1, 1991·Journal of Bacteriology·W G WeisburgD J Lane
Apr 28, 2004·Emerging Infectious Diseases·Robert M M SmithBrian O'Neill
Jul 8, 2005·Journal of Clinical Microbiology·Matjaz OcepekMario Poljak
Apr 16, 2010·Epidemiology and Infection·C ProbstM Kramer
May 22, 2010·Journal of Medical Microbiology·G PanteixS Godreuil
Aug 4, 2010·Emerging Infectious Diseases·Kathleen A AlexanderNicolaas C Gey van Pittius
Oct 22, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Rocío M Rivera, Lynda B Bennett
Dec 17, 2011·Emerging Infectious Diseases·Beatriz RomeroLucía de Juan
Apr 4, 2012·Emerging Infectious Diseases·Jakko van IngenDick van Soolingen
Aug 28, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Michele Miller, Francisco Olea-Popelka
Feb 15, 2013·Journal of Clinical Microbiology·Janina DomogallaMathias Büttner
May 10, 2013·BMC Veterinary Research·Tyler C ThackerWade Ray Waters
Apr 1, 2008·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Simone Rodrigues AmbrosioMarcos Amaku
Nov 28, 2013·Emerging Infectious Diseases·Sven D C ParsonsPaul D van Helden
Mar 14, 2014·Cell and Tissue Research·Anon Srikiatkhachorn, Christina F Spiropoulou

❮ Previous
Next ❯

Citations

Mar 19, 2016·Transboundary and Emerging Diseases·C MengeT Homeier
Sep 22, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sanne Christine van KampenBruce Kirenga
Mar 6, 2019·Annals of Global Health·Ploy PongwittayapanuChathaya Wongrathanandha
Dec 26, 2018·Frontiers in Veterinary Science·Smaragda TsairidouAndrea B Doeschl-Wilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.