Mycobacterium tuberculosis growth following aerobic expression of the DosR regulon.

PloS One
Kyle J MinchDavid R Sherman

Abstract

The Mycobacterium tuberculosis regulator DosR is induced by multiple stimuli including hypoxia, nitric oxide and redox stress. Overlap of these stimuli with conditions thought to promote latency in infected patients fuels a model in which DosR regulon expression is correlated with bacteriostasis in vitro and a proxy for latency in vivo. Here, we find that inducing the DosR regulon to wildtype levels in aerobic, replicating M. tuberculosis does not alter bacterial growth kinetics. We conclude that DosR regulon expression alone is insufficient for bacterial latency, but rather is expressed during a range of growth states in a dynamic environment.

References

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Citations

Nov 6, 2012·Nucleic Acids Research·Tige R RustadDavid R Sherman
Aug 12, 2014·Tuberculosis·Tatiana KondratievaAlexander Apt
Nov 2, 2016·Journal of Bacteriology·Pilar DomenechMichael B Reed
Jan 13, 2015·Nature Communications·Kyle J MinchDavid R Sherman
May 16, 2015·Scientific Data·Serdar TurkarslanNitin S Baliga
Mar 7, 2017·Frontiers in Immunology·Vidyullatha PeddireddyNiyaz Ahmed
Sep 6, 2018·The Journal of Biological Chemistry·Atul VashistJosephine E Clark-Curtiss
Sep 16, 2017·Trends in Microbiology·Ashley V Veatch, Deepak Kaushal
Dec 9, 2014·Microbiology Spectrum·Dirk Schnappinger, Sabine Ehrt

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Datasets Mentioned

BETA
GPL14896
GSE33752

Methods Mentioned

BETA
chemical treatment

Software Mentioned

ArrayStar
NimbleScan
GenePix

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