Mycobacterium tuberculosis-Infected Hematopoietic Stem and Progenitor Cells Unable to Express Inducible Nitric Oxide Synthase Propagate Tuberculosis in Mice

The Journal of Infectious Diseases
Stephen T ReeceStefan H E Kaufmann

Abstract

Persistence of Mycobacterium tuberculosis within human bone marrow stem cells has been identified as a potential bacterial niche during latent tuberculosis. Using a murine model of tuberculosis, we show here that bone marrow stem and progenitor cells containing M. tuberculosis propagated tuberculosis when transferred to naive mice, given that both transferred cells and recipient mice were unable to express inducible nitric oxide synthase, which mediates killing of intracellular bacteria via nitric oxide. Our findings suggest that bone marrow stem and progenitor cells containing M. tuberculosis propagate hallmarks of disease if nitric oxide-mediated killing of bacteria is defective.

References

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Citations

Oct 31, 2018·The Journal of Infectious Diseases·Jonathan MayitoAdrian R Martineau
Dec 1, 2019·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Stefan H E Kaufmann
Sep 4, 2019·The Journal of Clinical Investigation·Shabaana A KhaderUNKNOWN Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18
Feb 3, 2021·The Journal of Clinical Investigation·W Henry BoomJacqueline M Achkar
Jul 28, 2021·Tuberculosis·Bartolo TamburiniNadia Caccamo
Aug 21, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Deodutta RoySeyed Ehtesham Hasnain

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