Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis.

Mucosal Immunology
Elsa Du BruynCatherine Riou

Abstract

Recent data from mice and non-human primate models of tuberculosis suggested that CD153, a TNF super family member, plays an important role in Mycobacterium tuberculosis (Mtb) control. However, this molecule has not been comprehensively evaluated in humans. Here, we show that the proportion of Mtb-specific CD4 T cells expressing CD153 was significantly reduced in active TB patients compared to latently infected persons. Importantly, the CD153+ Mtb-specific CD4 response inversely correlated with lung bacterial load, inferred by Xpert cycle threshold, irrespective of HIV status. Antitubercular treatment partially restored CD153 expression on Mtb-specific CD4 T cells. This is the first report of a subset of Mtb-specific CD4 T cells showing strong negative correlation with bacterial burden. Building on substantial evidence from animal models implicating CD153 as a mediator of host protection, our findings suggest it may play a similar role in humans and its measurement may be useful to evaluate TB vaccine efficacy.

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Citations

Mar 23, 2021·Immunological Reviews·Jeffrey MorganCecilia S Lindestam Arlehamn
Jul 2, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rashmi TippalagamaJulie G Burel
Aug 5, 2021·The Journal of Experimental Medicine·Andrea C BohrerKatrin D Mayer-Barber
Aug 28, 2021·Frontiers in Immunology·Elisa PetruccioliDelia Goletti

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

TreeStar
FlowJo

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