PMID: 6984030Nov 1, 1982Paper

Mycolase II: an enzyme antifungal agent interacts with the polyene antibiotic pimaricin in the treatment of keratomycosis

International Ophthalmology
E O Oji

Abstract

An animal model of keratomycosis was used to study the interaction between the new enzyme antifungal compound mycolase II and the polyene antifungal antibiotic pimaricin. Well established corneal infection caused by an ocular pathogenic candida albicans on New Zealand white male rabbits were treated with 3% mycolase II, 5% pimaricin and a combination of 3% mycolase II and 5% pimaricin respectively. The rates of resolution of the corneal lesions for each group of eyes treated by the various drugs were determined and the results were analysed by computer using a two-way analysis of variance to determine the interaction or independence of 3% mycolase II in combination therapy with 5% pimaricin in rabbit keratomycosis. The analysis of variance showed a significant level of positive interaction after each period of treatment. (P less than 0.001).

References

Sep 1, 1979·Postgraduate Medical Journal·A M Pope, D A Davies
May 18, 1978·Nature·D A Davies, A M Pope
May 1, 1975·American Journal of Ophthalmology·B R Jones
Mar 1, 1970·American Journal of Ophthalmology·E NewmarkH E Kaufman
Jan 1, 1970·Annual Review of Pharmacology·S C Kinsky

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Citations

Jul 19, 2013·Critical Reviews in Biotechnology·Anand NagpureRajinder K Gupta

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