Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice

BioMed Research International
Jung-Woo SeoJu-Young Moon

Abstract

Chronic low-grade inflammation is an important factor in the pathogenesis of diabetic complication. Mycophenolate mofetil (MMF) has an anti-inflammatory effect, inhibiting lymphocyte proliferation. Previous studies showed attenuation of diabetic nephropathy with MMF, but the underlying mechanisms were unclear. This study aimed to identify the effect of MMF on diabetic nephropathy and investigate its action mechanisms in type 2 diabetic mice model. Eight-week-old db/db and control mice (db/m mice) received vehicle or MMF at a dose of 30 mg/kg/day for 12 weeks. MMF-treated diabetic mice showed decreased albuminuria, attenuated mesangial expansion, and profibrotic mRNA expressions despite the high glucose level. The number of infiltrated CD4(+) and CD8(+) T cells in the kidney was significantly decreased in MMF-treated db/db mice and it resulted in attenuating elevated intrarenal TNF-α and IL-17. The renal chemokines expression and macrophages infiltration were also attenuated by MMF treatment. The decreased expression of glomerular nephrin and WT1 was recovered with MMF treatment. MMF prevented the progression of diabetic nephropathy in db/db mice independent of glycemic control. These results suggest that the effects of MMF in d...Continue Reading

References

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Citations

Mar 10, 2016·Oxidative Medicine and Cellular Longevity·Abraham Said Arellano-BuendíaHoracio Osorio-Alonso
Jul 13, 2019·International Journal of Molecular Sciences·Keiichiro MatobaRimei Nishimura
Nov 17, 2020·Expert Review of Clinical Pharmacology·Eloi ChevallierJohan Noble

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
protein assay
PCR

Software Mentioned

ImageJ

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