Mycophenolate mofetil in pediatric heart transplant recipients: a single-center experience

Pediatric Transplantation
A I DipchandL West

Abstract

Mycophenolate mofetil (MMF) is emerging as an effective agent for the treatment of both established rejection and primary rejection prophylaxis in solid-organ transplantation (Tx). However, little data is available on the use of MMF in the pediatric population. We therefore report on our experience with MMF in 21 pediatric heart transplant recipients. Data were obtained by retrospective chart review. Median age at time of review was 12.3 yr (range 11 months to 16.9 yr). Median age at Tx was 10.7 yr (range 55 days to 16.7 yr). MMF was started at a median of 4.3 months after Tx (range 1 day to 4.5 yr). At the time of MMF institution, all patients were concurrently on prednisone and azathioprine; 20 of these patients were also undergoing treatment with tacrolimus (median dose 0.18 mg/kg, range 0.03-0.64 mg/kg) and one with cyclo-sporin A (10 mg/kg). Azathioprine was discontinued at the time of commencing MMF. The average MMF dose was 40 +/- 14 mg/kg. The rationale for switching to MMF included rejection (International Society for Heart and Lung Transplantation [ISHLT] 3A/B), 66%; inability to wean steroids, 14%; ABO blood group donor-recipient mismatch, 10%; coronary artery disease (CAD), 5%; and side-effects of immuno-suppression...Continue Reading

References

Mar 1, 1997·Current Opinion in Cardiology·D O Taylor
Apr 16, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S A BirkelandN Rohr
May 21, 1998·Current Opinion in Cardiology·J A Kobashigawa
Jul 1, 1998·Clinical Pharmacokinetics·R E BullinghamB R Kamm
Sep 2, 1998·Transplantation Proceedings·R B Ettenger

❮ Previous
Next ❯

Citations

Aug 28, 2003·Current Treatment Options in Cardiovascular Medicine·Subash C. ReddySteven A. Webber
Jul 23, 2008·International Ophthalmology Clinics·Manfred ZierhutChristoph Deuter
Jul 8, 2016·Journal of Clinical Pharmacology·Frédérique RodieuxJohannes N van den Anker
Jul 25, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mara MedeirosGuido Filler
Oct 28, 2005·Transplantation·Jon A Kobashigawa, Bruno M Meiser
Jul 2, 2009·Paediatric Drugs·Srilakshmi M SharmaAthimalaipet V Ramanan
Sep 17, 2014·Expert Opinion on Pharmacotherapy·Kyungmin LeeC Stephen Foster
Mar 6, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Rakesh K SinghKeith Fester
Aug 19, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Astrid E LammersMichael Burch
Feb 28, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido FillerMara Medeiros
May 25, 2007·Neuro-oncology·Brian Patrick O'NeillCaterina Giannini
Apr 24, 2012·British Journal of Clinical Pharmacology·Heather J DowningRosalind L Smyth
Aug 26, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sylvie Di FilippoAndré Bozio
Aug 17, 2006·Pediatric Transplantation·D A Kelly
Sep 25, 2007·Transplantation Proceedings·B DíazUNKNOWN MITOS Study Group
Jan 12, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Erin L OhmannSteven A Webber
Jul 21, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Maria Rosa CostanzoUNKNOWN International Society of Heart and Lung Transplantation Guidelines

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.