Mycophenolate mofetil in the treatment of adults with advanced rheumatoid arthritis: three 24-week, randomized, double-blind, placebo- or ciclosporin-controlled trials.

Clinical Drug Investigation
Michael SchiffMichelle Rashford

Abstract

Mycophenolate mofetil is an immunosuppressive agent approved for the prophylaxis of renal, cardiac and hepatic transplant rejection. With its proven immunosuppressive effects and favourable toxicity profile, mycophenolate mofetil was postulated as a potential candidate for treating rheumatoid arthritis. To evaluate the efficacy and safety profile of mycophenolate mofetil in the treatment of adults with advanced refractory rheumatoid arthritis. The effectiveness of mycophenolate mofetil (1 g twice daily) in the treatment of advanced refractory rheumatoid arthritis was assessed in three 24-week, randomized, double-blind, parallel-group trials (two placebo-controlled [n = 229 and n = 214] and one with ciclosporin 2.5-4 mg/kg/day as a comparator [n = 842]). Patients had American Rheumatism Association functional class II or III disease, a mean disease duration of 9.8-13 years, and had failed treatment with a median of three to four disease-modifying antirheumatic drugs. Overall, 959/1262 (76%) of patients in the main analysis group were female and 1189/1262 (94%) were Caucasian. In the placebo-controlled trials, the American College of Rheumatology 20% responder index rate did not differ significantly between mycophenolate mofetil ...Continue Reading

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Citations

Aug 30, 2012·Zeitschrift für Rheumatologie·K KrügerUNKNOWN European League of Associations for Rheumatology (EULAR)
Nov 26, 2015·Survey of Ophthalmology·Madeleine J HawkinsAdam H Ross
Jul 13, 2016·Drugs & Aging·Su-Ann YeohRichard Hull
Mar 7, 2020·Current Opinion in Rheumatology·Bryant R England, Daniel Hershberger
Apr 25, 2019·Clinical Rheumatology·Ana Catarina DuarteMaria José Santos
Jan 28, 2021·American Journal of Ophthalmology·James T RosenbaumDongseok Choi
Jan 18, 2021·Dermatologic Therapy·Layal AntouryCarol E Cheng

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