Mycophenolate mofetil-induced colitis in a patient with systemic sclerosis

BMJ Case Reports
Gianluca MoronciniArmando Gabrielli

Abstract

We present the case of a 44-year-old woman affected by systemic sclerosis (SSc) who was admitted to our department for abdominal pain, nausea, vomiting and fever. Imaging studies showed the presence of a thickened colon wall involving the descending colon and the sigma, while a subsequent endoscopy revealed multiple serpiginous ulcers covered with fibrin and exudates. Under the hypothesis of drug-induced colitis, mycophenolate mofetil (MMF), which she was taking for SSc-related interstitial lung disease (ILD), was readily suspended, with a rapid recovery without further treatment. A follow-up colonoscopy showed the complete resolution of the ulcers. This is the first case of MMF-induced colitis in a patient being treated for SSc-ILD.

References

Mar 31, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Megan K SelbstDhanpat Jain
Oct 1, 2013·The American Journal of Surgical Pathology·Kremena V StarRobert D Odze
Jul 19, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Giuseppina AbignanoFrancesco Del Galdo
Feb 25, 2015·Autoimmunity Reviews·Michele IudiciGabriele Valentini
Dec 13, 2016·Annals of the Rheumatic Diseases·Otylia Kowal-BieleckaUNKNOWN EUSTAR Coauthors
Jan 31, 2017·Journal of Scleroderma and Related Disorders·Andrew B ShreinerDinesh Khanna

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Citations

Aug 3, 2018·Digestive Diseases and Sciences·Swathi PaletiDenis McCarthy
Aug 22, 2020·World Journal of Gastroenterology : WJG·Yezaz A GhouriBo Shen

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