Mycophenolate mofetil (MMF) treatment efficacy in children with primary and secondary glomerulonephritis.

Archives of Medical Science : AMS
Danuta Ostalska-NowickaMichal Nowicki

Abstract

The aim of our study was to analyse the efficacy and safety of mycophenolate mofetil (MMF) as part of the complex immunosuppressive therapy in children with different types of primary and secondary glomerulonephritis, who were not eligible for the standard treatment routine suggested by evidence-based guidelines. The study group comprised 85 children with proteinuric glomerulopathies hospitalized between 2007 and 2010, who were non-responders to immunosuppressive therapy. The dose of MMF was established as 1 g/m(2)/24 h. Remission was defined as negative proteinuria in three consecutive urinalyses. The patients were divided into 4 groups: idiopathic nephrotic syndrome (n = 35), primary glomerulonephritis (n = 15), auto-antibody associated glomerulonephritis (n = 20) and lupus nephropathy (LN, n = 15). Ten patients from the first group (29%) and 5 patients each from the second and third group (34% and 25% respectively) did not respond to MMF therapy. On the other hand, all the children diagnosed with LN have reached clinical and biochemical remission. Alternative rescue MMF therapy should always be taken into consideration in proteinuric patients who are non-responders to steroids, cyclosporine A and cyclophosphamide in whom the...Continue Reading

Citations

Feb 5, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·George K Bertsias, Dimitrios T Boumpas
Jun 24, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Joanna SobiakMaria Chrzanowska
Jun 18, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnes HacklLutz Thorsten Weber
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joanna SobiakDanuta Ostalska-Nowicka

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