Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus.

Arthritis Research & Therapy
Sebastian EickenbergAnnett M Jacobi

Abstract

Clinical trials revealed a high efficacy of mycophenolate mofetil (MMF)in inducing and maintaining remission in patients with class III-V-lupus nephritis. Also extrarenal manifestations respond to MMF treatment. However, few attempts have been undertaken to delineate its mechanism of action in systemic lupus erythematosus (SLE) a disease characterized by enhanced B cell activation. Clinical and paraclinical parameters of 107 patients with SLE were recorded consecutively and analyzed retrospectively. Patients were divided into treatment groups (MMF: n=39, azathioprine (AZA) n=30 and controls without immunosuppressive therapy n=38). To further delineate the effect of mycophenolic acid (MPA) on naive and memory B cells in vitro assays were performed. Although patients taking AZA flared more frequently than patients on MMF or controls, the analysis of clinical parameters did not reveal significant differences.However, profound differences in paraclinical parameters were found. B cell frequencies and numbers were significantly higher in patients taking MMF compared to those on AZA but lower numbers and frequencies of plasmablasts were detected compared to AZA-treated patients or controls. Notably, MMF treatment was associated with a...Continue Reading

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Citations

Jul 6, 2014·Current Infectious Disease Reports·Daire O'SheaAdrian Egli
Nov 14, 2014·SpringerPlus·Zahra RezaieyazdiShahram Honarmand
Sep 26, 2015·Current Opinion in Allergy and Clinical Immunology·Fatima Dhalla, Siraj A Misbah
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Oct 6, 2020·Frontiers in Immunology·Desmond Y H YapTak Mao Chan

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Methods Mentioned

BETA
biopsy
density gradient centrifugation
FACS

Software Mentioned

GraphPad Prism5
FlowJo
FACS Diva

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