PMID: 8588242Dec 1, 1995Paper

Mycophenolic acid: measurement and relationship to pharmacologic effects

Therapeutic Drug Monitoring
L M Shaw, I Nowak

Abstract

Validated high-performance liquid chromatographic (HPLC) methods have been developed for the reliable measurement in plasma of mycophenolate mofetil (MMF), mycophenolic acid (MPA), its pharmacologically active metabolite, and mycophenolic acid glucuronide (MPAG), the inactive and primary metabolite of MPA. Using these validated HPLC methods, the pharmacokinetic behavior of MMF has been characterized in renal transplant patients as part of double-blind randomized multicenter clinical trials. The analytical performance characteristics of the HPLC methods are described. Based on investigations of the metabolism of MMF in animals, normal volunteers, and renal transplant patients, it has been established that MMF is rapidly converted to MPA. MPAG is the primary urinary excretion product derived from MPA. In vitro binding studies have revealed that MPA is extensively bound to plasma proteins and that human serum albumin is the primary binding protein. Pharmacokinetic studies have revealed the following: (1) MPA exhibits enterohepatic circulation in humans as a result of biliary excretion of MPAG followed by MPA production in the gastrointestinal tract and the appearance of secondary MPA peaks in plasma; (2) chronic renal impairment p...Continue Reading

Citations

Aug 29, 1998·Clinical Biochemistry·L M ShawK L Brayman
Sep 2, 1998·Transplantation Proceedings·R PuggiaA Vianello
Dec 29, 1998·Transplantation Proceedings·F BraunB Ringe
Nov 16, 1996·Lancet·J J Lipsky
Apr 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B M MeiserB Reichart
May 1, 1997·The American Journal of the Medical Sciences·P F Halloran
Jan 11, 2001·Transplantation·R BanerjeeN R Banner
Feb 21, 2002·Inflammatory Bowel Diseases·Maeve M SkellyChristopher J Hawkey
Jun 16, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·G SeebacherM M Müller
Jan 5, 2011·Expert Opinion on Drug Metabolism & Toxicology·Spyridoula DoukakiMaria Rita Bongiorno
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Jill S Warrington, Leslie M Shaw
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Maria ShipkovaEberhard Wieland
Jun 5, 2003·Clinical Transplantation·Ronald P PelletierRonald M Ferguson
Mar 13, 2014·Biopharmaceutics & Drug Disposition·Takaaki KodawaraMikio Masada
Jun 5, 2004·Gastroenterology Clinics of North America·Conor G LoftusWilliam J Sandborn
Feb 29, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Helieh S Oz, Jeffrey L Ebersole
Sep 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Markus J BartenRandall E Morris
Feb 25, 2000·Therapeutic Drug Monitoring·H U Meier-KriescheB Kaplan
Jul 20, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Olivier Bernard, Chantal Guillemette

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