Mycoplasma genitalium Infection in Kenyan and US Women

Sexually Transmitted Diseases
Jennifer E BalkusR Scott McClelland

Abstract

Little is known about the natural history of Mycoplasma genitalium (MG) infection in women. We retrospectively tested archived vaginal fluid samples to assess MG prevalence, incidence, persistence, recurrence and antimicrobial resistance markers among women participating in the Preventing Vaginal Infections trial, a randomized trial of monthly presumptive treatment to reduce vaginal infections. High-risk, nonpregnant, HIV-negative women aged 18 to 45 years from Kenya and the United States were randomized to receive metronidazole 750 mg + miconazole 200 mg intravaginal suppositories or placebo for 5 consecutive nights each month for 12 months. Clinician-collected swabs containing cervicovaginal fluid were tested for MG using Hologic nucleic acid amplification testing at enrollment and every other month thereafter. Specimens that were MG+ underwent additional testing for macrolide resistance-mediating mutations by DNA sequencing. Of 234 women enrolled, 221 had available specimens and 25 (11.3%) had MG at enrollment. Among 196 women without MG at enrollment, there were 52 incident MG infections (incidence, 33.4 per 100 person-years). Smoking was independently associated with incident MG infection (adjusted hazard ratio, 3.02; 95% ...Continue Reading

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Citations

Oct 12, 2018·Expert Review of Molecular Diagnostics·Barbara Van Der Pol
Oct 27, 2018·BioMed Research International·Ana Clara Correia MelgaçoCarla Cristina Romano
Aug 9, 2020·Tobacco Induced Diseases·Chen JiangMingxuan Xie
Oct 4, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sarah S RomanoLisa E Manhart
Oct 13, 2020·Sexually Transmitted Diseases·Emily RowlinsonLisa E Manhart

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