Mycoplasma hominis infection of Trichomonas vaginalis is not associated with metronidazole-resistant trichomoniasis in clinical isolates from the United States.

Parasitology Research
Sara E ButlerW Evan Secor

Abstract

Trichomonas vaginalis is a protozoan parasite that is the cause of the most common non-viral sexually transmitted disease, trichomoniasis. Metronidazole and tinidazole are the only drugs approved for treatment of T. vaginalis infections in the USA. However, drug resistance exists and some patients are allergic to these medications. Furthermore, the exact mechanism of metronidazole resistance remains undefined and current testing methods require several weeks before results are available. Identification of the mechanism of drug resistance may lead to the development of molecular tools to detect drug resistance, and quicker results for clinical treatment. In a recent study, Chinese T. vaginalis isolates that were polymerase chain reaction (PCR) positive for Mycoplasma hominis DNA demonstrated greater in vitro resistance to metronidazole than isolates with no evidence of M. hominis infection. To evaluate this finding in isolates from a distinct epidemiologic setting, we tested 55 T. vaginalis isolates collected from patients in the USA through the Centers for Disease Control and Prevention metronidazole susceptibility testing service. One half of the isolates demonstrated resistance to metronidazole by an in vitro sensitivity assa...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D V QuonP J Johnson
Jun 1, 1967·The British Journal of Venereal Diseases·P DurelM T Bassoullet
Dec 15, 1984·American Journal of Obstetrics and Gynecology·H MinkoffW M McCormack
Mar 1, 1997·Sexually Transmitted Diseases·B JacobsZ A Berege
Jun 20, 1998·Clinical Microbiology Reviews·D PetrinG Garber
Oct 27, 1998·Lancet·P RappelliP L Fiori
Jul 6, 2000·Journal of Clinical Microbiology·H MaytaA Vivar
Jul 10, 2001·The Journal of Reproductive Medicine·G SchmidH Moreno
Aug 15, 2002·Microbiology·Dominique RasolosonJaroslav Kulda
Mar 26, 2003·Antimicrobial Agents and Chemotherapy·Andrea L CrowellW Evan Secor
Sep 17, 2003·Cell Research·Rebecca L DunneJacqueline A Upcroft
Nov 28, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R G VanciniM Benchimol

❮ Previous
Next ❯

Citations

Nov 11, 2014·Critical Reviews in Microbiology·Thomas EdwardsGlyn Hobbs
Mar 30, 2016·Bioorganic & Medicinal Chemistry Letters·Patrícia de Brum VieiraTiana Tasca
Jul 15, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Débora da Luz BeckerTiana Tasca
Mar 16, 2017·Chemical Biology & Drug Design·Travis KoroshNigel Yarlett
Dec 2, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·K KubiakE Dzika
Jan 26, 2018·Parasitology Research·Ursula FürnkranzJulia Walochnik
Jan 9, 2019·Parasitology·Daniele DessìPaola Rappelli
Mar 25, 2018·Parasitology Research·Fernanda Gobbi BitencourtTiana Tasca
Jul 14, 2017·Frontiers in Microbiology·Anastasios IoannidisStylianos Chatzipanagiotou
Aug 6, 2020·Current Drug Targets·Graziela Vargas Rigo, Tiana Tasca
Apr 4, 2017·Research in Microbiology·Raina FichorovaPier Luigi Fiori

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.