Mycoplasma pneumoniae : A significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections

The Indian Journal of Medical Research
Surinder Kumar

Abstract

Lower respiratory tract infections are considered a common cause responsible for morbidity and mortality among children, and Mycoplasma pneumoniae is identified to be responsible for up to 40 per cent of community-acquired pneumonia in children greater than five years of age. Extrapulmonary manifestations have been reported either due to spread of infection or autoimmune mechanisms. Infection by M. pneumoniae has high incidence and clinical importance but is still an underrated disease. Most widely used serologic methods are enzyme immunoassays for detection of immunoglobulin M (IgM), IgG and IgA antibodies to M. pneumoniae, though other methods such as particle agglutination assays and immunofluorescence methods are also used. Detection of M. pneumoniae by nucleic acid amplification techniques provides fast, sensitive and specific results. Utilization of polymerase chain reaction (PCR) has improved the diagnosis of M. pneumoniae infections. Besides PCR, other alternative amplification techniques include (i) nucleic acid sequence-based amplification, (ii) Qβ replicase amplification, (iii) strand displacement amplification, (iv) transcription-mediated amplification, and (v) ligase chain reaction. Macrolides are used as the first...Continue Reading

Citations

Nov 14, 2019·The Indian Journal of Medical Research·Sanchit KumarSeema Kapoor
Aug 17, 2019·Royal Society Open Science·Thaís Cristina Vilela RodriguesSiomar de Castro Soares
Sep 4, 2019·Insect Biochemistry and Molecular Biology·Sooa LimIn Hee Lee
Mar 6, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marvah MahmoodUsman Ali Ashfaq
Jun 26, 2021·The Journal of International Medical Research·Li LiuHuan-Ji Cheng

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
by light
nucleic acid amplification
PCR
bronchoalveolar
lavage
biosensing
genosensor

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Related Papers

Korean journal of pediatrics
You-Sook Youn, Kyung-Yil Lee
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
W RastawickiR Gierczyñski
Enfermedades infecciosas y microbiología clínica
Lurdes Matas AndreuVicente Ausina Ruiz
© 2022 Meta ULC. All rights reserved