PMID: 11897994Mar 19, 2002Paper

Mycoplasma pneumoniae-induced activation and cytokine production in rodent mast cells

The Journal of Allergy and Clinical Immunology
Kristen L HoekT Prescott Atkinson

Abstract

Mycoplasma pneumoniae is a respiratory tract pathogen that has been associated with severe exacerbations in patients with chronic asthma. Murine models of infection have recently been established, with disease manifestations similar to those observed in human subjects. Previous studies have suggested that this organism is capable of producing activation of a wide range of immunologic cell types. We sought to determine whether M pneumoniae can induce mast cell activation in the rodent mast cell line RBL-2H3. After 4 hours of coculture, morphologic changes indicative of activation were observed by means of electron microscopy, and M pneumoniae was identified, by means of immunoelectron microscopy, adhering to mast cell membranes. Coculture of rat basophilic leukemia cells with viable M pneumoniae for 4 hours resulted in net release of beta-hexosaminidase and serotonin into the supernatant. Live, but not heat-killed, organisms induced the release of IL-4 protein into the culture supernatant, with a peak at 4 hours. During coculture with M pneumoniae, production of mRNA for IL-4, IL-6, and TNF-alpha was upregulated after 2 hours and had returned to near baseline by 24 hours after infection. We conclude that viable M pneumoniae indu...Continue Reading

Citations

Sep 2, 2003·Pediatric Pulmonology·Ken B Waites
Aug 30, 2008·FEMS Microbiology Reviews·Thomas Prescott AtkinsonKen B Waites
Dec 25, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaolan WuJilu Tang
Apr 18, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Lan Fang TangZhi Min Chen
Aug 16, 2015·BMC Genomics·Li XiaoKevin Dybvig
Jan 30, 2004·Current Opinion in Pulmonary Medicine·Mario CazzolaFrancesco Blasi
Oct 19, 2004·Clinical Microbiology Reviews·Ken B Waites, Deborah F Talkington
Mar 6, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Anna-Carla DefilippiGiovanni A Rossi
Feb 6, 2016·Iranian Journal of Pediatrics·Wei LiHui Xu
Dec 1, 2008·Expert Review of Respiratory Medicine·Urvashi BhanTheodore J Standiford
Nov 4, 2011·Immunologic Research·Jordan Wesolowski, Fabienne Paumet
Dec 21, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Serena PanigadaGiovanni A Rossi
Jan 7, 2017·Journal of Tropical Pediatrics·Biljana MedjoSlobodanka Djukic
Oct 8, 2005·American Journal of Respiratory and Critical Care Medicine·Xiang XuGeorge H Caughey
Mar 30, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N M MichelsR J Martin
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Joshua A Boyce
Aug 5, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Joshua A Boyce

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