PMID: 9537752Apr 16, 1998Paper

Mycoplasma salivarium induces interleukin-6 and interleukin-8 in human gingival fibroblasts

FEMS Immunology and Medical Microbiology
K ShibataT Watanabe

Abstract

Analysis by an enzyme-linked immunosorbent assay for cytokines indicated that whole cells, intracellular materials and cell membranes of Mycoplasma salivarium induced interleukin-6 and interleukin-8 in a human gingival fibroblast cell line, Gin-1 cells. This was confirmed by reverse transcription-polymerase chain reaction analysis of mRNAs of these cytokines. Studies with inhibitors of second-messenger pathway indicated that a protein kinase C-dependent pathway was involved in the expression of the activity of the cell membranes. In addition, whole cells of other mycoplasmas (M. hominis, M. arthritidis, M. arginini, M. fermentans, M. penetrans, M. pirum and M. pneumoniae) tested for comparative purposes were also shown to possess the activity. Thus, this study demonstrated that mycoplasmas possess the activity to induce interleukin-6 and interleukin-8 in human fibroblasts.

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Citations

Feb 17, 2009·The Journal of Biological Chemistry·Kazuki TawaratsumidaMasahito Hashimoto
Feb 7, 2007·Infection and Immunity·Masahito HashimotoYasuo Suda
Aug 30, 2008·Journal of Clinical Microbiology·Andrea J GrisoldEgon Marth
Aug 15, 2009·Chembiochem : a European Journal of Chemical Biology·Yukari FujimotoKoichi Fukase
Jun 6, 2013·Archives of Oral Biology·J D KornspanS Rottem
Jan 20, 2006·FEMS Immunology and Medical Microbiology·Kazuto KiuraKen-ichiro Shibata
Sep 13, 2006·FEMS Immunology and Medical Microbiology·Kazuto KiuraKen-ichiro Shibata
Dec 24, 2005·International Immunology·Masahito HashimotoYasuo Suda
Jul 6, 2006·Cellular Microbiology·Hideo KataokaKen-Ichiro Shibata
Mar 7, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Taher AzimiHossein Dabiri

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