Abstract
Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. We previously reported that the prognosis of MF patients is not only related on clinical variables but it is also associated with peculiar HLA alleles. Until today, the association of HLA ligands for KIR with the prognosis of the disease has not yet been analysed. We investigated the frequency of HLA ligands for killer cell Immunoglobulin-like receptors (KIRs) in MF patients, evaluating if the presence of particular HLA alleles that are ligands for KIR may have prognostic value. The study includes 46 Caucasian MF patients that, between 1993 and 1997, underwent HLA genomic typing. All patients were diagnosed and followed up from 1977 to 2012 (mean follow-up of 11 years). MF patients have been divided into two groups (long survivors and dead patients). We noticed that the HLA-Bw6/Bw6 specificity increased among the group of seven dead patients compared to the group of 39 long survivors (71.4% vs. 41.0%, P = ns, OR = 3.59), while in the long survivors group the HLA- Bw4/Bw4 specificity increased when compared to dead patients (23.0% vs. 0%, P = ns). Moreover, we observed that six of the seven dead patients had HLA-DQB1*05; the phenotypic frequency of this HLA all...Continue Reading
References
May 1, 1983·The Journal of Investigative Dermatology·B SafaiM S Pollack
Sep 1, 1996·The Journal of Investigative Dermatology·C M JackowM Duvic
Mar 20, 2002·The British Journal of Dermatology·E HodakK Klein
Jul 23, 2003·Archives of Dermatology·Youn H KimRichard T Hoppe
Sep 30, 2003·Diabetes·Arno R van der SlikMarius J Giphart
Oct 24, 2007·Critical Reviews in Oncology/hematology·Pier Luigi ZinzaniLorenzo Cerroni
Mar 13, 2009·Blood·Porcia T BradfordJorge R Toro
Oct 29, 2009·Current Pharmaceutical Design·Roberto BiassoniAndrea De Maria
Jan 18, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Rafijul BariWing Leung
Jan 24, 2012·Current Opinion in Immunology·Ariane ThielensFrançois Romagné
May 11, 2012·Genes and Immunity·C CapittiniM Martinetti
May 7, 2013·Journal of Dermatological Science·Łukasz MatusiakJacek C Szepietowski
Jun 6, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E C BentonS J Whittaker
Feb 19, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·V BrazzelliG Borroni
Citations
Jul 17, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·V BrazzelliG Borroni
Sep 9, 2017·HLA : Immune Response Genetics·L-Q ZhangJ-P Cai
Aug 29, 2019·Experimental Dermatology·Biao ChenYanhua Liang
Dec 3, 2015·Current Hematologic Malignancy Reports·Catherine G Chung, Brian Poligone