Mycosis fungoides: HLA class II associations among Ashkenazi and non-Ashkenazi Jewish patients

The British Journal of Dermatology
Emmilia HodakK Klein

Abstract

An immunogenetic mechanism has been suggested to play a role in the pathogenesis of mycosis fungoides (MF). While results of studies on HLA class I associations haveproved inconsistent, two previous studies showed that certain HLA class II alleles were significantly increased among North American caucasian patients with MF: HLA-DRB1*11 and DQB1*03. To investigate the possible HLA class I and class II associations with MF among Jewish patients. The patient group comprised 68 Jewish patients with MF: 38 Ashkenazi and 30 non-Ashkenazi. The control group comprised 252 healthy Jewish volunteers: 132 Ashkenazi and 120 non-Ashkenazi. Tissue typing for HLA class I (A and B) was performed using the National Institutes of Health microlymphocytotoxicity technique. DNA-based low-medium resolution analysis for DRB1* and DQB1* alleles was performed using polymerase chain reaction (PCR) amplification with sequence-specific primers. For those alleles found to have significantly increased frequency, high-resolution analysis was done by means of PCR sequence-specific oligotyping. The allele frequency of HLA-DRB1*11 was found to be significantly increased but only among Ashkenazi patients with MF (30% vs. 19% in the controls; P = 0.034). High-res...Continue Reading

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Citations

Nov 2, 2004·Familial Cancer·Henry T LynchGershon Y Locker
Mar 12, 2005·Journal of the American Academy of Dermatology·Emmilia HodakMichael David
Nov 27, 2015·American Journal of Hematology·Ryan A Wilcox
Mar 2, 2005·The Journal of Investigative Dermatology·Eric C VonderheidJ Steve Hou
Dec 2, 2014·Journal of the American Academy of Dermatology·Emmilia Hodak, Iris Amitay-Laish
Mar 5, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Marc BeyerWolfram Sterry
Oct 13, 2011·American Journal of Hematology·Ryan A Wilcox
Jul 22, 2014·American Journal of Hematology·Ryan A Wilcox
Jul 29, 2004·Journal of the American Academy of Dermatology·Emma Guttman-YasskyRonit Sarid
Sep 10, 2010·Clinical Lymphoma, Myeloma & Leukemia·Emmila Hodak, Eitan Friedman
Sep 10, 2010·Clinical Lymphoma, Myeloma & Leukemia·James T Elder
Jul 18, 2019·American Journal of Hematology·Alexandra C HristovRyan A Wilcox
Sep 28, 2017·Archives of Dermatological Research·Ofer ReiterEmmilia Hodak
Jun 4, 2019·Journal of Internal Medicine·C ZhongS S Wang
Jul 1, 2008·Journal of Neuro-oncology·Delia KurzwellyUlrich Herrlinger
Mar 11, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·V BrazzelliG Borroni
Jul 24, 2021·American Journal of Hematology·Alexandra C HristovRyan A Wilcox

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