Mycothiol-dependent mycobacterial response to oxidative stress

FEBS Letters
Korine S E Ung, Yossef Av-Gay

Abstract

The effect of exogenous oxidative stress on mycothiol (MSH) levels and redox balance was investigated in mycobacteria. Both the thiol-specific oxidant diamide and hydrogen peroxide induced up to 75% depletion of MSH to form the disulfide form, mycothione (MSSM), in Mycobacterium bovis BCG. In comparison, Mycobacterium smegmatis, a saprophytic mycobacterium, displays a greater tolerance towards these oxidants, reflected by the lack of fluxes in MSH levels and redox ratios upon oxidative stress treatments. The basal ratio of MSH to MSSM was established to be 50:1 in M. bovis BCG and 200:1 in M. smegmatis.

References

Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·D R ShermanC K Stover
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·J D MacMickingC F Nathan
Feb 26, 2000·Infection and Immunity·A M CooperI M Orme
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·C Nathan, M U Shiloh
Nov 7, 2002·Archives of Microbiology·Gerald L Newton, Robert C Fahey
Oct 7, 2003·Annual Review of Microbiology·Josephine E Clark-Curtiss, Shelley E Haydel
Oct 15, 2003·Biochemistry·Micah SteffekRobert C Fahey
Nov 5, 2003·Journal of Bacteriology·Dipti SareenNancy A Buchmeier
Jun 23, 2004·Tuberculosis·D G Niranjala MuttucumaruTanya Parish
Jul 12, 2005·FEMS Microbiology Letters·Nirpjit S DosanjhYossef Av-Gay

❮ Previous
Next ❯

Citations

Nov 10, 2011·The Journal of Biological Chemistry·Ján BurianCharles J Thompson
Jul 20, 2007·Antimicrobial Agents and Chemotherapy·Christopher C MillerYossef Av-Gay
Apr 15, 2008·Journal of Bacteriology·Hiromi TakaradaShigeaki Harayama
Sep 6, 2008·Microbiology and Molecular Biology Reviews : MMBR·Gerald L NewtonRobert C Fahey
Aug 4, 2011·PLoS Pathogens·Stavroula K Hatzios, Carolyn R Bertozzi
Nov 26, 2008·Natural Product Reports·Vishnu Karthik Jothivasan, Chris J Hamilton
Jul 20, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·David P Giedroc, Alphonse I Arunkumar
Jul 19, 2011·Ecotoxicology and Environmental Safety·José Sebastián Dávila CostaCarlos Mauricio Abate
Feb 7, 2008·Biochimica Et Biophysica Acta·Chris D den Hengst, Mark J Buttner
Sep 11, 2007·Biochemical and Biophysical Research Communications·Mamta RawatYossef Av-Gay
Mar 22, 2016·Microbial Pathogenesis·N D PatelM A Peteroy-Kelly
Feb 9, 2007·FEMS Microbiology Reviews·Mamta Rawat, Yossef Av-Gay
Sep 17, 2011·Organic Letters·Chuan-Chung ChungShang-Cheng Hung
Apr 5, 2017·Antioxidants & Redox Signaling·Aníbal M ReyesMadia Trujillo
Aug 1, 2015·The Journal of Biological Chemistry·Melissa Richard-GreenblattYossef Av-Gay
Oct 18, 2019·Antioxidants & Redox Signaling·Parminder Singh MaviAshwani Kumar
Apr 15, 2020·Infection and Immunity·Kelly L MichieMarvin Whiteley
Apr 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Catherine VilchèzeWilliam R Jacobs
Nov 23, 2017·Frontiers in Microbiology·Yesha S Patel, Sarika Mehra
Feb 14, 2018·Antimicrobial Agents and Chemotherapy·C Sao EmaniC Carolis
Jul 13, 2018·Journal of Biomedical Science·C Sao EmaniB Baker
Apr 8, 2021·Microbiology·Leah Isobella Rankine-WilsonYossef Av-Gay
Jun 25, 2015·Microbiology Spectrum·Bridgette M CummingAdrie J C Steyn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.