Mycotoxins - Their Biosynthesis in Fungi: Ochratoxins - Metabolites of Combined Pathways

Journal of Food Protection
William E Huff, Pat B Hamilton

Abstract

Little work has been done on the biosynthesis of ochratoxins. Nevertheless. a scheme based on known chemical and enzymatic reactions and incorporating known facts about ochratoxin biosynthesis is proposed as a working model. The scheme calls for formation of an unbranched pentaketide from acetyl and malonyl CoA, its cyclization and aromatization to an is ocoumarin, methylation and oxidation to the carboxy derivative which is chlorinated by chloroperoxidase before acyl activation for reaction with an ester of phenylalanine which arises via the shikimic acid pathway. The amide, ochratoxin A, is considered the final product of this biosynthetic pathway.

Citations

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Sep 6, 2020·Toxicon : Official Journal of the International Society on Toxinology·Pradeep KumarSukni Bui

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