MyD-88 L265P mutations are present in some cases of vitreoretinal lymphoma

Retina
Jose S PulidoDavid S Viswanatha

Abstract

To determine whether Myd88 L265P mutations occur in diffuse large B-cell vitreoretinal lymphomas. The formalin-fixed paraffin-embedded cells from three patients with classic clinical findings of vitreoretinal lymphoma that also had histologic confirmation were evaluated using a validated amplification-refractory mutation system polymerase chain reaction to determine the presence of the mutation. The 74 ± 2 base pair product seen from the mutated Myd-88 protein was noted in 2 of the 3 cases. Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. Further studies on the incidence of this mutation in retinal lymphomas are warranted.

References

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Citations

Dec 15, 2015·Retina·Jose S PulidoDavid S Viswanatha
Sep 8, 2015·American Journal of Ophthalmology·Rodolfo MastropasquaLyndon da Cruz
Aug 17, 2018·Acta Ophthalmologica·Ester CarrenoJoya Pawade
Apr 20, 2018·Clinical & Experimental Ophthalmology·Abby C DawsonJustine R Smith
Apr 2, 2019·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Dimitrios KalogeropoulosChris Kalogeropoulos
Sep 26, 2020·Indian Journal of Ophthalmology·Sandhya NarasimhanKrishnakumar Subramanian
May 16, 2018·International Journal of Retina and Vitreous·Jose S PulidoHarish Raja
Oct 23, 2020·The British Journal of Ophthalmology·Mona MohammadMandeep S Sagoo
Feb 15, 2020·Survey of Ophthalmology·Alexandra L Farrall, Justine R Smith
Jul 24, 2021·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Aug 28, 2021·Cancers·Bianka SobolewskaManfred Zierhut

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