MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.

The Journal of Experimental Medicine
Rosalba SalcedoGiorgio Trinchieri

Abstract

Signaling through the adaptor protein myeloid differentiation factor 88 (MyD88) promotes carcinogenesis in several cancer models. In contrast, MyD88 signaling has a protective role in the development of azoxymethane (AOM)/dextran sodium sulfate (DSS) colitis-associated cancer (CAC). The inability of Myd88(-/-) mice to heal ulcers generated upon injury creates an altered inflammatory environment that induces early alterations in expression of genes encoding proinflammatory factors, as well as pathways regulating cell proliferation, apoptosis, and DNA repair, resulting in a dramatic increase in adenoma formation and progression to infiltrating adenocarcinomas with frequent clonal mutations in the beta-catenin gene. Others have reported that toll-like receptor (Tlr) 4-deficient mice have a similar susceptibility to colitis to Myd88-deficient mice but, unlike the latter, are resistant to CAC. We have observed that mice deficient for Tlr2 or Il1r do not show a differential susceptibility to colitis or CAC. However, upon AOM/DSS treatment Il18(-/-) and Il18r1(-/-) mice were more susceptible to colitis and polyp formation than wild-type mice, suggesting that the phenotype of Myd88(-/-) mice is, in part, a result of their inability to ...Continue Reading

References

Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Aug 28, 2003·Scandinavian Journal of Gastroenterology·H TakagiT Hibi
Dec 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sarah L PullThaddeus S Stappenbeck
Feb 5, 2005·Journal of Gastroenterology·Akihiro ArakiMamoru Watanabe
Mar 15, 2005·The Journal of Clinical Investigation·Kyoko KatakuraEyal Raz
Apr 14, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Masayuki FukataMaria T Abreu
Mar 17, 2006·Cancer Research·Christopher F BasilEna Wang
May 24, 2006·The Journal of Experimental Medicine·Toshikatsu HanadaAkihiko Yoshimura
Oct 26, 2006·Nature Reviews. Immunology·Gavin P DunnRobert D Schreiber
Jan 4, 2007·The Journal of Clinical Investigation·Sarah L BrownThaddeus S Stappenbeck
Mar 6, 2007·Seminars in Nephrology·Charles A Dinarello
Mar 16, 2007·Nature·Arianna NenciManolis Pasparakis
Mar 17, 2007·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·A M ChromikU Mittelkötter
Jul 7, 2007·Science·Seth Rakoff-Nahoum, Ruslan Medzhitov
Oct 24, 2007·World Journal of Gastroenterology : WJG·Lorena Rodriguez-BoresJesus-K Yamamoto-Furusho
Nov 17, 2007·The Journal of Clinical Investigation·Matam Vijay-KumarAndrew T Gewirtz
Dec 7, 2007·Gastroenterology·Masayuki FukataMaria T Abreu
Dec 12, 2007·World Journal of Gastroenterology : WJG·Lorena Rodríguez-BoresJesús K Yamamoto-Furusho
Jan 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeremy B SwannMark J Smyth
Apr 24, 2008·The Journal of Clinical Investigation·Matthias ErnstBrendan J Jenkins
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shipra VaishnavaLora V Hooper
Sep 8, 2009·Cancer Cell·Wendy S GarrettLaurie H Glimcher
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove

❮ Previous
Next ❯

Citations

Nov 20, 2012·Seminars in Immunopathology·Sergei I Grivennikov
Mar 9, 2012·Targeted Oncology·Nadège GoutagnyChristophe Caux
Feb 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qingchao ZhuHuanlong Qin
May 11, 2013·Trends in Immunology·Rosalba SalcedoGiorgio Trinchieri
Jul 3, 2013·Microbes and Infection·Paras K Anand, Thirumala-Devi Kanneganti
Dec 15, 2010·Cell Research·Andy WullaertManolis Pasparakis
Mar 22, 2013·Mucosal Immunology·M Fukata, M Arditi
Mar 21, 2012·Nature Immunology·Laurence ZitvogelGuido Kroemer
Sep 20, 2012·Nature Immunology·Romina S Goldszmid, Giorgio Trinchieri
Jun 20, 2013·Nature Immunology·Eric M BrownB Brett Finlay
Dec 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bo HuRichard A Flavell
Aug 4, 2010·The Journal of Experimental Medicine·Mark Asquith, Fiona Powrie
Sep 18, 2013·The Journal of Experimental Medicine·Lukas NiederreiterArthur Kaser
Apr 10, 2013·Inflammatory Bowel Diseases·Klara KlimesovaHelena Tlaskalova-Hogenova
Apr 10, 2013·Inflammatory Bowel Diseases·Tiha M LongBret A Hassel
May 23, 2012·Current Opinion in Gastroenterology·Daniel A SussmanMaria T Abreu
Dec 23, 2011·Journal of Gastroenterology and Hepatology·Matthias Ernst, Robert G Ramsay
Feb 3, 2012·Biological Reviews of the Cambridge Philosophical Society·Annemarie Boleij, Harold Tjalsma
Nov 30, 2011·Cancer Research·Takashi TanikawaWeiping Zou
May 6, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meghan B DavisYoung J Kim
Apr 27, 2011·The Journal of Clinical Investigation·Gabriela SchiechlStefan Fichtner-Feigl
Jun 12, 2012·The Journal of Clinical Investigation·Jennifer A CalvoLeona D Samson
Oct 16, 2012·The Journal of Clinical Investigation·Vasiliki KoliarakiGeorge Kollias
Oct 31, 2012·International Journal of Molecular Sciences·Giovanni MonteleoneCarmine Stolfi
Aug 31, 2011·F1000 Medicine Reports·Giorgio Trinchieri
Apr 23, 2013·Mediators of Inflammation·Tiago Nunes, Heitor S de Souza
Dec 18, 2012·Immunotherapy·Hiroko Tsutsui, Kenji Nakanishi
Feb 13, 2014·Pharmacology & Therapeutics·Michela TerlizziRosalinda Sorrentino
Aug 13, 2013·Oncogene·J-P PradereR F Schwabe
Jan 12, 2011·Annual Review of Immunology·Beckley K DavisJenny P-Y Ting
Jan 12, 2011·Annual Review of Immunology·Matthew D VeselyMark J Smyth
Sep 15, 2012·Annual Review of Cell and Developmental Biology·Mohamed Lamkanfi, Vishva M Dixit
Oct 18, 2013·Nature Reviews. Cancer·Robert F Schwabe, Christian Jobin
Jun 5, 2016·Biochemistry. Biokhimii︠a︡·O S DmitrievaS I Grivennikov
Jun 3, 2014·International Journal of Molecular Sciences·Marianna Parlato, Garabet Yeretssian
Oct 6, 2015·Marine Drugs·Elena TaleroVirginia Motilva

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
ubiquitination
PCR
electrophoresis

Software Mentioned

Stanford Cluster
BLAST
Ingenuity Pathway
Cluster
Mutation Surveyor
TreeView
Primer
BRBArrayTools
BRB
ArrayTools

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis