MyD88 mediates the protective effects of probiotics against the arteriolar thrombosis and leukocyte recruitment associated with experimental colitis

Inflammatory Bowel Diseases
Daniele G SouzaD Neil Granger

Abstract

Several studies in patients with IBD and in animal models of IBD have revealed a protective effect of probiotics in reducing clinical symptoms of disease and in blunting the gut inflammation that accompanies this condition. However, the mechanism underlying the therapeutic effect of probiotics is currently unknown. Furthermore, the ability of probiotics to influence the enhanced thrombus development that accompanies IBD has not been studied. This study addresses whether the enhanced extraintestinal thrombosis (induced by light/dye injury) associated with experimental colitis is altered by oral treatment with the probiotic preparation VSL#3 or by the absence of microbiota. Colitis was induced by DSS 3% in Swiss Webster mice, germ-free mice, C57BL/6 WT, or Myd88 mice. In some experiments, mice received VSL#3 for 8 days before and during DSS feeding. Swiss Webster mice were also subjected to a chronic model of DSS colitis, and the effect of VSL#3 was evaluated. VSL#3 treatment significantly attenuated the accelerated thrombus formation observed in both acute and chronic models of colitis. VSL#3-treated mice also exhibited attenuated inflammatory response and injury in the colon. The protective effects of VSL#3 on colitis-associate...Continue Reading

References

Dec 9, 1998·Clinical and Experimental Immunology·L A DielemanE P Van Rees
Aug 17, 1999·European Journal of Pharmacology·I M MatosM M Teixeira
Aug 24, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·F HeitsW Jelkmann
Jun 10, 2004·Digestive Diseases and Sciences·Thorsten VowinkelD Neil Granger
Sep 1, 2004·European Journal of Pharmacology·Maureen N AjueborCory M Hogaboam
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle G SouzaMauro M Teixeira
Feb 5, 2005·Journal of Gastroenterology·Akihiro ArakiMamoru Watanabe
Mar 17, 2005·Blood·Bijoy ThattaliyathPudur Jagadeeswaran
Apr 9, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Rolando E RumbautAlan R Burns
Jul 8, 2005·Journal of Clinical Microbiology·Alexander SwidsinskiHerbert Lochs
Jan 27, 2006·World Journal of Gastroenterology : WJG·Silvio DaneseAntonio Gasbarrini
Aug 12, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sandra AnguloJulián Panés
Jun 15, 2007·The Journal of Experimental Medicine·Christoph AnthoniD Neil Granger
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
Jan 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·O SchreiberL Holm
Feb 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rudolf MennigenMatthias Bruewer
Mar 3, 2009·Inflammatory Bowel Diseases·Hideo Yoshida, D Neil Granger
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
May 16, 2009·Current Opinion in Gastroenterology·Cosimo Prantera, Maria Lia Scribano
Nov 7, 2009·The American Journal of Pathology·Angélica T VieiraMauro M Teixeira
Mar 3, 2010·Annual Review of Immunology·Arthur KaserRichard S Blumberg
Jun 22, 2010·Inflammatory Bowel Diseases·Joshua M UronisChristian Jobin
Oct 26, 2010·The American Journal of Pathology·Hideo YoshidaD Neil Granger
Nov 30, 2010·Nature Reviews. Microbiology·Gregor ReidHenk J Busscher
Oct 12, 2011·Inflammatory Bowel Diseases·Hideo YoshidaD Neil Granger
Nov 4, 2011·The New England Journal of Medicine·Silvio Danese, Claudio Fiocchi
Jan 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vy LamJohn E Baker
Apr 25, 2012·PloS One·Marina L Ritchie, Tamara N Romanuk
Jun 14, 2012·PLoS Pathogens·Seong Gyu JeonKiyoshi Takeda
Aug 24, 2012·Lancet·Daniel C Baumgart, William J Sandborn
Oct 25, 2012·Digestion·Peter L LakatosStephan Vavricka
Dec 12, 2012·Experimental and Therapeutic Medicine·Sheng-Lan WangChang-Qing Yang
Mar 23, 2013·Inflammatory Bowel Diseases·Serena L S YanD Neil Granger
Apr 10, 2013·Inflammatory Bowel Diseases·Klara KlimesovaHelena Tlaskalova-Hogenova
May 1, 2013·Seminars in Thrombosis and Hemostasis·Efstratios I KoutroumpakisIoannis E Koutroubakis
May 16, 2013·The American Journal of Pathology·Elena Y SenchenkovaD Neil Granger
Aug 30, 2013·American Journal of Physiology. Renal Physiology·Punithavathi RanganathanGanesan Ramesh
Oct 10, 2013·Molecular Nutrition & Food Research·Camelia Sorina StancuAnca Volumnia Sima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here