MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation

Molecular Psychiatry
D Gosselin, S Rivest

Abstract

Activation of neuronal circuits involved in the control of autonomic responses is critical for the host survival to immune threats. The brain vascular system plays a key role in such immune-CNS communication, but the signaling pathway and exact type of cells within the blood-brain barrier (BBB) mediating these functions have yet to be uncovered. To elucidate this issue we used myeloid differentiation factor 88 (MyD88)-deficient mice, because these animals do not show any responses to the cytokine interleukin-1beta (IL-1beta). We created chimeric mice with competent MyD88 signaling in either the BBB endothelium or perivascular microglia of bone marrow origin and challenged them with IL-1beta. Systemic treatment with the cytokine caused a robust transcriptional activation of genes involved in the prostaglandin E(2) (PGE(2)) production by vascular cells of the brain. Upregulation of these genes is dependent on a functional MyD88 signaling in the endothelium, because MyD88-deficient mice that received bone marrow stem cells from wild-type animals (for example, functional perivascular microglia) exhibited no response to systemic IL-1beta administration. MyD88 competent endothelial cells also mediate neuronal activation and plasma re...Continue Reading

References

Mar 15, 1997·Annals of the New York Academy of Sciences·C CaoY Watanabe
Oct 23, 1997·The Journal of Comparative Neurology·S Lacroix, S Rivest
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·C H SorliR P Robertson
Jan 26, 1999·Annals of the New York Academy of Sciences·K MatsumuraY Watanabe
Mar 22, 2001·Nature·M EkA Ericsson-Dahlstrand
Feb 28, 2002·Annual Review of Immunology·Jeanette I WebsterEsther M Sternberg
Jan 14, 2003·Annual Review of Immunology·Kiyoshi TakedaShizuo Akira
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Jennifer C Schiltz, Paul E Sawchenko
Sep 27, 2003·Acta Physiologica Scandinavica·W ZhangB C Kone
Oct 21, 2003·Nature Neuroscience·David EngblomAnders Blomqvist
Nov 26, 2003·Progress in Lipid Research·Makoto Murakami, Ichiro Kudo
Apr 16, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alain R Simard, Serge Rivest
Nov 4, 2004·Experimental Biology and Medicine·Nicolas P Turrin, Serge Rivest
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sumana Chakravarty, Miles Herkenham
Aug 6, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandre A SteinerAndrej A Romanovsky

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Citations

Dec 7, 2011·The Journal of Experimental Medicine·Dirk A RidderMarkus Schwaninger
Dec 17, 2008·Journal of Neuroinflammation·Bibhuti B MishraJudy M Teale
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brenda MarshMary P Stenzel-Poore
Oct 26, 2012·ISRN Neurology·Carina Mallard
Mar 23, 2013·Annual Review of Immunology·B DiamondB T Volpe
Feb 26, 2016·Neuroscience and Biobehavioral Reviews·B García BuenoJ C Leza
Dec 22, 2010·Pharmacology & Therapeutics·Reyna L VangilderJason D Huber
Aug 6, 2010·Brain Research Reviews·Filipa Lourenço CardosoMaria Alexandra Brito
Oct 14, 2009·Frontiers in Neuroendocrinology·Joshua P ThalerBrent E Wisse
Apr 4, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Julia F CharlesAntonios O Aliprantis
Aug 8, 2009·Journal of Neurochemistry·Paul M CarveyAngela J Monahan
Jun 26, 2012·Immunological Reviews·Marc-André Bellavance, Serge Rivest
Mar 29, 2014·The Journal of Comparative Neurology·Anna EskilssonAnders Blomqvist
Sep 27, 2015·Journal of Neuroinflammation·Chen JinGregory A Lodygensky
Aug 12, 2009·Neuroscience and Biobehavioral Reviews·Nicole DellaGioia, Jonas Hannestad
Dec 30, 2014·Molecular and Cellular Endocrinology·Waldemar KanczkowskiStefan R Bornstein
Jan 5, 2012·Frontiers in Neuroendocrinology·Michael A GalicQuentin J Pittman
Feb 16, 2010·Neuron·Jordi SerratsPaul E Sawchenko
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Waldemar KanczkowskiStefan R Bornstein
Apr 20, 2014·Frontiers in Immunology·Marc-André Bellavance, Serge Rivest
Sep 7, 2016·Behavioural Brain Research·Nan-Qu HuangFeng Jin
Sep 21, 2016·Chinese Medical Journal·Hong-Xing Wang, Yu-Ping Wang
Dec 8, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Giles S KendallGennadij Raivich
Dec 16, 2017·British Journal of Pharmacology·Aisling BamburyTimothy G Dinan
Oct 31, 2015·Intensive Care Medicine Experimental·Monique MichelsFelipe Dal-Pizzol
Nov 6, 2018·Journal of Cellular Physiology·Omid Reza TamtajiZatollah Asemi
Jan 29, 2016·Developmental Neurobiology·Fabrício SimãoMagda Lahourgue Nunes
Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Feb 12, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Johan RuudAnders Blomqvist
Jun 4, 2014·Molecular Endocrinology·Gerard ClarkeTimothy G Dinan
Jul 3, 2017·Journal of Neuroinflammation·Stephanie M KrasnowDaniel L Marks
Jun 4, 2018·Brain : a Journal of Neurology·Abel Torres-EspínKarim Fouad

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