Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family

Gene
J P MagyarUeli Suter

Abstract

An increasing number of four-transmembrane proteins has been found to be associated with CNS and PNS myelin. Some of these proteins play crucial roles in the development and maintenance of the nervous system. In the CNS, proteolipid protein (PLP) is mutated in the myelin disorder Pelizaeus-Merzbacher disease and in spastic paraplegia, while in the PNS, peripheral myelin protein 22 (PMP22) and connexin32 (C x 32) are culprit genes in the most frequent forms of hereditary peripheral neuropathies. Myelin and lymphocyte protein (MAL; also called MVP17 or VIP17) and plasmolipin are additional tetraspan proteins that are highly expressed by myelinating glial cells. However, little is known about the role of these proteins in the nervous system. As a prerequisite for functional genetic approaches in the mouse, we have isolated and characterized a mouse MAL cDNA and the corresponding structural MAL gene. Computer-aided analysis and database searches revealed that MAL belongs to a larger gene family which also includes plasmolipin, BENE and the expressed sequence tag (EST) H09290. While the overall amino acid sequence identities between mouse MAL and the related proteins are relatively low (29-37%), the conserved motif -[Q/Y-G-W-V-M-F/Y...Continue Reading

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Citations

Jul 22, 1998·Microscopy Research and Technique·R Naef, U Suter
May 15, 2001·International Journal of Cancer. Journal International Du Cancer·W El-RifaiS Knuutila
Mar 29, 2001·Microscopy Research and Technique·J CaduffN Schaeren-Wiemers
Mar 31, 2005·Molecular and Cellular Neurosciences·Tiziana VigoAngelo Schenone
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May 2, 2003·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kazuhiko WatabeNorie Araki
Jul 9, 1999·Molecular Biology of the Cell·C BrancoliniC Schneider
Dec 7, 2013·Multiple Sclerosis International·Judith M Greer
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·K H CheongK Simons
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Aug 1, 2019·American Journal of Physiology. Renal Physiology·Kubra M TunaAbdel A Alli
Dec 3, 1999·Journal of Neurochemistry·M C BirlingP J Brophy
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh

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