Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis

Annals of Neurology
P J TalbotF Ouellet

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating neurological disease in which autoreactive T lymphocytes sensitized to myelin components of the central nervous system are postulated to contribute to pathogenesis. The possible relevance of molecular mimicry between a human coronavirus and the myelin basic protein component of myelin in the generation of this autoimmune reaction was evaluated. Myelin basic protein- and virus-reactive T-cell lines were established from 16 MS patients and 14 healthy donors and shown to be mostly CD4+. In contrast to healthy donors, several T-cell lines isolated from MS patients showed cross-reactivity between myelin and coronavirus antigens. Overall, 29% of T-cell lines from MS patients (10 donors) but only 1.3% of T-cell lines from normal control subjects (2 donors) showed an HLA-DR-restricted cross-reactive pattern of antigen activation after in vitro selection with either myelin basic protein or human coronavirus strain 229E antigens. Moreover, reciprocal reactivities were only observed in MS patients (4 donors). This establishes molecular mimicry between a common viral pathogen, such as this human coronavirus, and myelin as a possible immunopathological mechanism in MS and is consisten...Continue Reading

References

May 1, 1976·Journal of the Neurological Sciences·R TanakaH Koprowski
Feb 1, 1992·Immunology Today·L SteinmanC C Bernard
May 1, 1992·Annals of Neurology·R S MurrayG F Cabirac
Feb 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L A Barnett, R S Fujinami
Sep 11, 1987·Cell·M B Oldstone
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·A M GautamH O McDevitt
Jan 29, 1994·Lancet·C Ffrench-Constant
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Jan 1, 1994·Annals of Neurology·J Hillert
Jan 1, 1994·Annals of Neurology·H S Panitch
Jun 1, 1994·The Journal of Experimental Medicine·L K SelinR M Welsh
Jan 1, 1993·Advances in Experimental Medicine and Biology·P J TalbotJ N Stewart
Oct 1, 1993·Clinical Microbiology Reviews·J F Kurtzke
Feb 1, 1993·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A D Sadovnick, G C Ebers

❮ Previous
Next ❯

Citations

Dec 1, 1996·Current Opinion in Immunology·M G von Herrath, M B Oldstone
Mar 11, 1998·Current Opinion in Immunology·S Hausmann, K W Wucherpfennig
Jan 1, 1997·Trends in Microbiology·T E Lane, M J Buchmeier
Sep 20, 2000·The Journal of Experimental Medicine·T BrabbJ Goverman
Sep 17, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rebecca A Sosa, Thomas G Forsthuber
Aug 18, 1999·Immunological Reviews·M S Horwitz, N Sarvetnick
Sep 12, 2000·Journal of Virology·N ArbourP J Talbot
Jun 20, 2003·Lancet·Fook Tim ChewChoy Leong Hew
Nov 17, 2012·Journal of the Neurological Sciences·Marcus W KochV Wee Yong
May 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Caroline LassnigMathias Müller
Jul 30, 1999·Journal of Neuroimmunology·J Antel
Oct 23, 1997·Journal of Neuroimmunology·R M NagraW F Reynolds
Jul 16, 2009·Seminars in Immunopathology·Simon HohenesterUlrich Beuers
Apr 26, 2005·FEBS Letters·Gopala Kovvali, Kiron M Das
Feb 10, 2016·Multiple Sclerosis and Related Disorders·P Conti, D Kempuraj
Mar 29, 2011·Neurologic Clinics·Gregory F Wu, Enrique Alvarez
Feb 15, 2008·Clinical Neurology and Neurosurgery·Silvia N Tenembaum
Apr 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Annie BoucherPierre J Talbot
Mar 16, 2007·Journal of Autoimmunity·Roman Rieger, M Eric Gershwin
May 8, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Laurine Legroux, Nathalie Arbour
Jun 13, 2006·Cellular Immunology·Xiao-Song HeM Eric Gershwin
Jul 17, 1999·Multiple Sclerosis : Clinical and Laboratory Research·S Schmidt
Oct 1, 1996·Nature Medicine·J P AntelT Owens
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·S E EpsteinD Hajjar
Feb 4, 2006·Autoimmunity·Bumseok KimBarry T Rouse
Feb 18, 2010·Expert Review of Clinical Immunology·Javid P Mohammed, Jochen Mattner
Mar 2, 2010·Expert Review of Neurotherapeutics·Klaus Lauer
Sep 28, 1999·Current Opinion in Neurology·G Martino, H P Hartung
Sep 2, 1998·Current Opinion in Neurology·R S Liblau, B Fontaine
Apr 1, 1997·Immunology and Cell Biology·J M Davies
Nov 13, 2015·Journal of Neuroinflammation·Carine SavarinStephen A Stohlman
Jul 3, 2020·Journal of Clinical Medicine·Francesco CappelloAlberto Jl Macario
Sep 2, 2020·Journal of Neurology·Maryline SanterreBassel E Sawaya
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A AmraniP Santamaria
Nov 8, 2017·Frontiers in Microbiology·Anjali GargManish Kumar

❮ Previous
Next ❯

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