PMID: 9532587Apr 9, 1998Paper

Myelin basic protein in cerebrospinal fluid and other body fluids

Multiple Sclerosis : Clinical and Laboratory Research
J N Whitaker

Abstract

Myelin basic protein (MBP) or a fragment thereof may enter cerebrospinal fluid (CSF) and other body fluids in an etiologically nonspecific fashion to provide information about the status of central nervous system (CNS) myelin damage. MBP immunochemically detected is referred to as MBP-like material (MBPLM). The clinical utility of the assay for MBPLM in CSF is to document the presence, continuation, or resolution of CNS myelin injury. The analysis of CSF for MBPLM is subject to many variables, among which are the antisera and the form of the assay utilized. The dominant epitope of CSF MBPLM is in the decapeptide of 80-89 from the intact MBP molecule of 170 residues. Normally, CSF has no detected MBPLM. Following an acute relapse of MS, MBPLM rises quickly in the range of ng/ml and rapidly declines and disappears. The presence of MBPLM in CSF in chronic and progressive phases of the disease is unusual, but it may sometimes be detected in low levels, depending on the assay used for detection. The level of CSF MBPLM is related to both the mass of CNS myelin damage and how recently it occurred. The level of CSF MBPLM rarely is elevated in optic neuritis. The level of CSF MBPLM is unrelated to CSF protein level, level of IgG, presen...Continue Reading

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Citations

Feb 13, 2003·Brain Pathology·Mikhail PashenkovHans Link
Mar 15, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Danielle E WhittakerHolger A Volk
Jul 18, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Erman EsnafogluTevfik Noyan
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Oct 6, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Lars BörnsenFinn Sellebjerg
Jan 27, 2019·AJNR. American Journal of Neuroradiology·C ÖzütemizA M McKinney
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Apr 24, 2009·Biochemistry·Michael D HoosWilliam E Van Nostrand
Apr 23, 2021·The Clinical Journal of Pain·Xin YangChangsheng Huang

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