PMID: 6169802Jan 1, 1981Paper

Myelin basic protein in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases

Journal of Neurology
A BiberK Hempel

Abstract

Cerebrospinal fluid (CSF) from 105 patients was analyzed by radioimmunoassay for the presence of material cross-reactive with peptide 89-169 of bovine myelin basic protein (BP). In a group of 72 multiple sclerosis patients, 52 showed higher BP content than the control group, i.e. more than 2 ng/ml CSF. Increased BP or BP fragments could be detected in CSF from almost all patients who recently (within 2 weeks) had had an acute episode, or after deterioration in the progressive form of the disease. Fifteen to 30 days after the onset of exacerbation or in a stable period, BP content decreases and in the slowly progressive form was in the range of the control group with one exception. BP content was also elevated in the CSF of patients with other neurological diseases. The presence of BP in the CSF from patients with isolated retrobulbar neuritis is of particular interest. Thus the presence of material cross-reactive with BP fragment 89-169 is not specific for multiple sclerosis, but is a useful parameter in diagnosis and evaluation of MS.

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Citations

Jan 1, 1985·Journal of Neurology·J Matias-GuiuJ M Martinez-Vazquez
Jul 1, 1989·Journal of Neurology·H W PfisterJ R Bogner
Jun 1, 1983·Italian Journal of Neurological Sciences·J N Whitaker
Dec 1, 1990·Italian Journal of Neurological Sciences·A R MassaroP Tonali
Jan 1, 1983·Neurochemistry International·N P GroomeJ Appleby
Nov 1, 1996·Acta Neurologica Scandinavica·J L Frederiksen, J N Whitaker
Apr 14, 1984·British Medical Journal·N R HoyleD G Thomas
Feb 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·D G ThomasP Seeldrayers
Oct 1, 1983·Journal of Neuroimmunology·C A DowseC C Bernard
Jan 1, 1987·Critical Reviews in Clinical Laboratory Sciences·M K Gupta
Jan 1, 1984·Annals of the New York Academy of Sciences·J N Whitaker
May 14, 2011·Biochemical and Biophysical Research Communications·Orsolya VinczeJudit Ovádi
Jul 23, 2013·PloS One·Christophe FraisierLionel Almeras
Feb 13, 1999·Multiple Sclerosis : Clinical and Laboratory Research·F SellebjergJ L Frederiksen
Oct 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·K J LamersW J von Geel
Dec 1, 1985·Acta Neurologica Scandinavica·A J ThomsonM Hutchinson
Sep 1, 1986·Annals of Neurology·J N WhitakerO F Smith

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