Myelin changes at the early stage of 5XFAD mice

Brain Research Bulletin
Li-Hua GuZhi-Jun Zhang

Abstract

Previous studies have demonstrated myelin deficits in Alzheimer's disease (AD). However, it is still unclear whether myelin deficits occur at early stage of AD. Our study aimed to investigate myelin deficits in 5XFAD mice dynamically in different cognition-associated brain regions at early stage of AD. Transmission electron microscopy (TEM) was applied to detect myelin changes in late-myelinating regions such as prelimbic area (PrL), retrosplenial granular cortex (Rsg), field CA1 of hippocampus (CA1) and entorhinal cortex (ERC) respectively at different stages (1, 2, 3 and 5 months of age) in 5XFAD mouse model. In addition, we assessed spatial learning and memory with Morris water maze (MWM) in 5XFAD mice. Myelin deficits in 5XFAD mice started from 1 month of age and this deterioration continued during ageing, whereas the same myelin abnormality could only be observed in 5-month-old wild-type mice. Additionally, the g-ratio (an index associated with myelin thickness) was increased in 1-month-old 5XFAD mice in the regions including PrL, CA1 and ERC, compared to wild-type mice. As animals aged, the increased g-ratio in 5XFAD appeared in more regions of the brain. Moreover, 5XFAD mice showed spatial memory deficits from 1 month of...Continue Reading

Citations

Sep 11, 2018·The Journal of Comparative Neurology·Dara L DicksteinCharles L Limoli
Dec 11, 2019·Antioxidants·Donald G MatthewsAmala Soumyanath
Apr 8, 2020·Neuropathology and Applied Neurobiology·I Ferrer, P Andrés-Benito
Jan 9, 2020·Journal of Neuroscience Research·Filip KoselTamara B Franklin
Oct 27, 2018·International Journal of Molecular Medicine·Zhenhua LiuXiaoting Wang
Feb 19, 2021·Alzheimer's Research & Therapy·Simone M CrivelliPilar Martinez-Martinez
Feb 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shreyan Majumdar, Dieter Klatt
Apr 18, 2021·Computers in Biology and Medicine·Zhiwei JiXiaobo Zhou
Dec 9, 2021·Physical Chemistry Chemical Physics : PCCP·Mayuri Gupta, Donald F Weaver

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