Myelin-induced experimental allergic encephalomyelitis in Lewis rats: tumor necrosis factor alpha levels in serum and cerebrospinal fluid immunohistochemical expression in glial cells and macrophages of optic nerve and spinal cord

Journal of Neuroimmunology
H VillarroyaN Baumann

Abstract

Tumor necrosis factor alpha (TNFalpha) activity was measured in serum and cerebrospinal fluid (CSF) of Lewis rats after experimental allergic encephalomyelitis (EAE) induction and during the clinical course of acute disease. TNFalpha bioactivity expression preceded the clinical symptoms and paralleled the severity of disease. We further investigated the identity of the central nervous system (CNS) cells involved in TNFalpha expression and their regional localization during EAE. Tissue sections of brain, cerebellum, dorsal spinal cord and optic nerve were studied by indirect double labelling immunofluorescence. Spinal cord white matter and optic nerve showed a widespread TNFalpha immunoreactivity at critical stages of EAE in macrophages/microglia and astrocytes. We have shown changes in CSF/serum albumin ratio and immunoglobulin G index during EAE. Our results confirm the very important role of TNFalpha in EAE.

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Citations

Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K J BeckerJ M Hallenbeck
Jul 7, 2012·Acta Neuropathologica·Wolfgang BrückChristiane Wegner
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Sep 26, 2020·Frontiers in Cellular Neuroscience·Melanie J PlastiniRoberta Brambilla
Apr 19, 2011·Journal of Anatomy·Besma NashSusan C Barnett
Nov 29, 2020·Glia·Sofia Pereira das NevesFernanda Marques
Sep 25, 1997·Journal of Neuroscience Research·H VillarroyaN Baumann
Jul 10, 2012·Journal of Proteome Research·Marcel P StoopRainer Bischoff
Feb 11, 2012·Journal of Proteome Research·Therese RosenlingTheo M Luider

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