Myelin oligodendrocyte glycoprotein antibodies are associated with a non-MS course in children

Neurology. Neuroimmunology and Neuroinflammation
Yael HacohenPatrick Waters

Abstract

To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS). Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) were identified from 2 national demyelination programs in the United Kingdom and France. Acute serum samples were tested for MOG-Abs by cell-based assay. Antibodies were used to predict diagnosis of multiple sclerosis (MS) at 1 year. Twenty-three of 65 (35%) children had MOG-Abs. Antibody-positive and antibody-negative patients were not clinically different at presentation, but identification of MOG-Abs predicted a non-MS course at 1-year follow-up: only 2/23 (9%) MOG-Ab-positive patients were diagnosed with MS compared to 16/42 (38%) MOG-Ab-negative patients (p = 0.019, Fisher exact test). Antibody positivity at outset was a useful predictor for a non-MS disease course, with a positive predictive value of 91% (95% confidence interval [CI] 72-99), negative predictive value of 38% (95% CI 24-54), positive likelihood ratio of 4.02 (CI 1.0-15.4), and odds ratio of 6.5 (CI 1.3...Continue Reading

Citations

Mar 1, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Renu SutharPratibha Singhi
Jul 22, 2015·International Journal of Molecular Sciences·Anne-Katrin PröbstelTobias Derfuss
Dec 29, 2015·Autoimmunity Reviews·Sudarshini RamanathanFabienne Brilot
Sep 9, 2015·Multiple Sclerosis and Related Disorders·Sanduni KariyawasamMing Lim
May 9, 2016·The Journal of Allergy and Clinical Immunology·Chrysanthi SkevakiCatherine A Thornton
Aug 2, 2016·Lancet Neurology·Todd A HardyBrian G Weinshenker
Feb 27, 2016·Developmental Medicine and Child Neurology·Yael HacohenAngela Vincent
Oct 12, 2016·Journal of Ophthalmology·Huanfen ZhouShihui Wei
Nov 8, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Helene VerhelstRudy Van Coster
Dec 10, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Christian LechnerKevin Rostásy
Dec 22, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W J Brownlee, O Ciccarelli
Dec 3, 2016·Expert Opinion on Pharmacotherapy·Emanuele D'AmicoFrancesco Patti
Jul 23, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Silvia Tenembaum
Mar 2, 2017·Current Opinion in Neurology·Markus ReindlThomas Berger
Feb 25, 2017·Current Opinion in Neurology·Russell C DaleMing Lim
Mar 10, 2018·Nature Reviews. Neurology·Ruth GeraldesUNKNOWN MAGNIMS study group
Nov 23, 2017·Arquivos de neuro-psiquiatria·Tarso Adoni
Dec 31, 2017·Developmental Medicine and Child Neurology·Yael HacohenCheryl Hemingway
Feb 15, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y Y M WongR F Neuteboom
Apr 10, 2018·Current Opinion in Neurology·Kevin Rostásy, Barbara Bajer-Kornek
Nov 17, 2017·Neurodegenerative Disease Management·Angelo Ghezzi
Jun 2, 2018·Developmental Medicine and Child Neurology·Michael EyreMing Lim
Sep 15, 2017·The British Journal of Ophthalmology·Delphine Averseng-PeaureauxUNKNOWN Kidbiosep study group
Jun 22, 2018·Nature Reviews. Neurology·Elizabeth WellsUNKNOWN attendees of the International Neuroimmune Meeting
Jan 24, 2019·Current Treatment Options in Neurology·Yael Hacohen, Brenda Banwell
May 9, 2019·Physiological Reviews·Christine StadelmannMikael Simons
May 17, 2019·Multiple Sclerosis : Clinical and Laboratory Research·C L de MolR Q Hintzen
Dec 12, 2018·Practical Neurology·Maciej JuryńczykJacqueline Palace
Jun 5, 2016·Continuum : Lifelong Learning in Neurology·Sona Narula, Brenda Banwell
Nov 13, 2019·Nature Reviews. Neuroscience·Joseph J SabatinoScott S Zamvil
Apr 27, 2018·Neurology·Alvaro Cobo-CalvoUNKNOWN OFSEP and NOMADMUS Study Group
Apr 7, 2017·Neurology·Yael HacohenRogier Hintzen
Aug 5, 2017·Neurology·Eva-Maria HennesUNKNOWN BIOMARKER Study Group
Jun 16, 2017·Neurology·Yael HacohenCheryl Hemingway
Dec 15, 2019·Neurology. Neuroimmunology and Neuroinflammation·Álvaro Cobo-CalvoRomain Marignier
Feb 7, 2020·Neurology. Neuroimmunology and Neuroinflammation·Markus ReindlPatrick Waters
Apr 16, 2019·Current Opinion in Neurology·Hans-Peter HartungMichael H Barnett
Aug 23, 2019·Current Opinion in Ophthalmology·Jane H LockJason H Peragallo
Feb 15, 2019·Current Opinion in Neurology·Alvaro Cobo-CalvoRomain Marignier
May 16, 2020·Brain : a Journal of Neurology·Yoshiki TakaiUNKNOWN Japan MOG-antibody Disease Consortium

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Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad Prism
SPSS

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