Myelin oligodendrocyte glycoprotein antibody-associated demyelination: comparison between onset phenotypes

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Y ZhouWei Qiu

Abstract

The aim of this study was to analyse the clinical and prognostic features of myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination with different onset phenotypes. A total of 52 MOG-IgG-seropositive patients were divided into four groups: (i) optic neuritis (ON) at onset (MOG-ON+ , n = 23), (ii) transverse myelitis (TM) at onset (MOG-TM+ , n = 12), (iii) pure brain symptoms at onset (MOG-ON- -TM- , n = 14) and (iv) both ON and TM at onset (n = 3). This final group was not included in further analyses. Data were collected through medical records and regular follow-up. Median age at presentation was 24 (range, 3-63) years in the whole cohort (50% female). MOG-ON- -TM- patients had the youngest age of onset across the three groups. Patients with MOG-TM+ tended to relapse more frequently and had a longer interval to first relapse than was observed in MOG-ON+ and MOG-ON- -TM- patients. High MOG-IgG titres were associated with increased cerebrospinal fluid leukocytes. The likelihood of harbouring transient, low MOG-IgG titres was higher in the MOG-TM+ group than in the other groups. After a median disease duration of 20 months, most but not all cases had a favourable outcome, with 8% developing severe visual def...Continue Reading

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Jul 8, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Jae-Won HyunHo Jin Kim
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Citations

Sep 19, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N ShorR Deschamps
May 21, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Xiaobo SunLisheng Peng
Oct 14, 2020·Revue neurologique·N ShorUNKNOWN NOMADMUS study group
Jun 26, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Makoto MoriMasahito Yamada

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