Myelin Oligodendrocyte Glycoprotein-antibody-associated Disorder Presenting with Corticomeningeal Encephalitis prior to the Onset of Optic Neuritis.

Internal Medicine
Takuya AtakaEtsuro Matsubara

Abstract

We herein report a case of myelin oligodendrocyte glycoprotein-antibody-associated disorder (MOG-AD) presenting with corticomeningeal encephalitis. The patient exhibited oral ulceration, a mild impairment of consciousness, fever, nausea, nuchal rigidity, positivity for human leukocyte antigen type B51, and neutrophil-dominant pleocytosis and interleukin-6 level in cerebrospinal fluid (CSF). Magnetic resonance imaging (MRI) revealed a right temporal lesion with leptomeningeal gadolinium enhancement. The initial diagnosis was neuro-Behçet's disease presenting with meningoencephalitis; however, a cell-based assay detected anti-MOG antibody in the serum and CSF and the patient also experienced bilateral optic neuritis. After administering steroid therapy, his neurologic symptoms and CSF abnormalities improved along with the disappearance of gadolinium enhancement and the lesion on MRI. This case suggests that MOG-AD may present with corticomeningeal encephalitis prior to the onset of optic neuritis.

References

Jan 24, 2009·Lancet Neurology·Adnan Al-Araji, Desmond P Kidd
Feb 28, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·UNKNOWN International Team for the Revision of the International Criteria for Behçet's Disease (ITR-ICBD)
Jan 21, 2017·Neurology. Neuroimmunology and Neuroinflammation·Ryo OgawaKazuo Fujihara
Feb 18, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Juichi FujimoriKazuo Fujihara
Jul 12, 2017·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Kerrie-Anne ChenPeter Ian Andrews
Oct 10, 2018·Multiple Sclerosis and Related Disorders·Ram N NarayanBenjamin Greenberg
May 21, 2019·Journal of Neuroimmunology·Divya NagabushanaAnita Mahadevan
Jul 7, 2019·Journal of Neuroimmunology·Juichi FujimoriIchiro Nakashima
Dec 31, 2019·Multiple Sclerosis and Related Disorders·Afshin Borhani-HaghighiLee Shapiro
Mar 23, 2020·Multiple Sclerosis and Related Disorders·Johanna LeinertTobias Tenenbaum
Jul 8, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Deepti VibhaManjari Tripathi
Sep 5, 2020·Journal of Neuroinflammation·Sven JariusUNKNOWN in cooperation with the Neuromyelitis Optica Study Group (NEMOS)
Jan 8, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Di NanTao Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2021 Meta ULC. All rights reserved