PMID: 7537310May 15, 1995Paper

Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis

The Journal of Immunology : Official Journal of the American Association of Immunologists
T G JohnsC C Bernard

Abstract

Chronic relapsing experimental autoimmune encephalomyelitis, a demyelinating disease induced by injection of central nervous system (CNS) tissue, is widely used as a model for multiple sclerosis. However, it is unclear which Ag or combination of Ags in the CNS induce the demyelinating immune response. We now show in Lewis rats that a single injection of myelin oligodendrocyte glycoprotein, a specific CNS myelin component, or an appropriately derived myelin oligodendrocyte glycoprotein peptide produces a relapsing remitting neurologic disease with extensive plaque-like demyelination. Igs from affected animals reacted specifically with myelin oligodendrocyte glycoprotein and stimulated a myelin protease activity, leading to myelin basic protein degradation. The demonstrated involvement of myelin oligodendrocyte glycoprotein as a new demyelinating neural Ag may provide a deeper insight into the pathogenesis of multiple sclerosis and its treatment.

Citations

Oct 3, 2001·The Journal of Experimental Medicine·J L McQualterC C Bernard
May 1, 2012·Brain : a Journal of Neurology·Steven PetratosClaude C A Bernard
Sep 17, 1998·The Journal of Clinical Investigation·R WeissertT Olsson
May 8, 2010·Journal of Neuropathology and Experimental Neurology·Steven PetratosClaude C A Bernard
Dec 18, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nicolas FissoloManuel Comabella
Dec 29, 2015·Autoimmunity Reviews·Sudarshini RamanathanFabienne Brilot
Sep 30, 2008·Brain Research Reviews·Eitan OkunThiruma V Arumugam

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