Aug 14, 2019

Myelin Water Fraction and Intra/Extracellular Water Geometric Mean T2 Normative Atlases for the Cervical Spinal Cord from 3T MRI

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Hanwen LiuCornelia Laule

Abstract

Acquiring and interpreting quantitative myelin-specific MRI data at an individual level is challenging because of technical difficulties and natural myelin variation in the population. To overcome these challenges, we used multiecho T2 myelin water imaging (MWI) to create T2 metric healthy population atlases that depict the mean and variation of myelin water fraction (MWF), and intra- and extracellular water mobility as described by geometric mean T2 (IEGMT2 ). Cervical cord MWI was performed at 3T on 20 healthy individuals (10M/10F, mean age: 36 years) and 3 relapsing remitting multiple sclerosis (RRMS) participants (1M/2F, age: 39/42/37 years). Anatomical data were collected for the purpose of image segmentation and registration. Atlases were created by coregistering and averaging T2 metrics from all controls. Voxel-wise z-score maps from 3 RRMS participants were produced to demonstrate the preliminary utility of the MWF and IEGMT2 atlases. The average MWF atlas provides a representation of myelin in the spinal cord consistent with well-known spinal cord anatomical characteristics. The IEGMT2 atlas also depicted structural variations in the spinal cord. Z-score analysis illustrated distinct abnormalities in MWF and IEGMT2 in ...Continue Reading

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Citations

Mentioned in this Paper

Study
Cervical Spinal Cord Injury
Magnetic Resonance Imaging
Metal Working Fluid
Laminectomy With Cordotomy, With Section of One Spinothalamic Tract, One Stage; Cervical
Participant
HOXB4 gene
3 Tesla Magnetic Resonance Imaging
Multiple Sclerosis, Relapsing-Remitting
Structure

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