Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study

Scientific Reports
Matthew D Sacchet, Ian H Gotlib

Abstract

Evidence from post-mortem, genetic, neuroimaging, and non-human animal research suggests that Major Depressive Disorder (MDD) is associated with abnormalities in brain myelin content. Brain regions implicated in this research, and in MDD more generally, include the nucleus accumbens (NAcc), lateral prefrontal cortex (LPFC), insula, subgenual anterior cingulate cortex (sgACC), and medial prefrontal cortex (mPFC). We examined whether MDD is characterized by reduced myelin at the whole-brain level and in NAcc, LPFC, insula, sgACC, and mPFC. Quantitative magnetic resonance imaging (qMRI) permits the assessment of myelin content, in vivo, in the human brain through the measure of R1. In this study we used qMRI to measure R1 in 40 MDD and 40 healthy control (CTL) participants. We found that the MDD participants had lower levels of myelin than did the CTL participants at the whole-brain level and in the NAcc, and that myelin in the LPFC was reduced in MDD participants who had experienced a greater number of depressive episodes. Although further research is needed to elucidate the role of myelin in affecting emotional, cognitive, behavioral, and clinical aspects of MDD, the current study provides important new evidence that a fundament...Continue Reading

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Citations

Feb 28, 2018·Depression and Anxiety·Daniel G DillonDiego A Pizzagalli
Oct 15, 2018·Journal of Personality·Nicola Toschi, Luca Passamonti
Feb 1, 2020·Current Topics in Medicinal Chemistry·Anna Todeva-RadnevaDrozdstoy St Stoyanov
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Nov 17, 2020·Frontiers in Human Neuroscience·Johanna C WalkerTiffany C Ho
Jul 24, 2020·Molecular Neurobiology·Leszek Rudzki, Michael Maes
Jul 4, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tiffany C HoIan H Gotlib

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Software Mentioned

mrQ
3dNwarpApply
3dUnifize
_ T1wSynthesis1
Analysis of Functional NeuroImages ( AFNI )
FreeView
FreeSurfer
3dSkullStrip

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