Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults

Brain Structure & Function
Tobias BrachtDavid Linden

Abstract

Recent evidence suggests that individual differences in physical activity (PA) may be associated with individual differences in white matter microstructure and with grey matter volume of the hippocampus. Therefore, this study investigated the association between PA and white matter microstructure of pathways connecting to the hippocampus. A total of 33 young, healthy adults underwent magnetic resonance imaging (MRI). High angular resolution diffusion-weighted imaging and multi-component relaxometry MRI scans (multi-component driven equilibrium pulse observation of T1 and T2) were acquired for each participant. Activity levels (AL) of participants were calculated from 72-h actigraphy recordings. Tractography using the damped Richardson Lucy algorithm was used to reconstruct the fornix and bilateral parahippocampal cinguli (PHC). The mean fractional anisotropy (FA) and the myelin water fraction (MWF), a putative marker of myelination, were determined for each pathway. A positive correlation between both AL and FA and between AL and MWF were hypothesized for the three pathways. There was a selective positive correlation between AL and MWF in the right PHC (r = 0.482, p = 0.007). Thus, our results provide initial in vivo evidence f...Continue Reading

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Citations

Sep 17, 2016·Social Neuroscience·George ZacharopoulosDavid E J Linden
Apr 22, 2017·Human Brain Mapping·Dusan HirjakKlaus H Maier-Hein
Jul 10, 2019·Physiology International·P D Loprinzi
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May 30, 2020·Journal of Psychiatry and Brain Science·Stewart A ShankmanSebastian Walther
Jun 9, 2021·Hippocampus·Sarah L AghjayanKirk I Erickson

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Software Mentioned

DESPOT2
SPSS22
McDESPOT
TBSS
FNIRT

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