PMID: 8992924Jan 1, 1997Paper

Myelinolysis after correction of hyponatremia

Annals of Internal Medicine
R Laureno, B I Karp

Abstract

Myelinolysis is a neurologic disorder that can occur after rapid correction of hyponatremia. Initially named "central pontine myelinolysis," this disease is now known to also affect extrapontine brain areas. Manifestations of myelinolysis usually evolve several days after correction of hyponatremia. Typical features are disorders of upper motor neurons, spastic quadriparesis and pseudobulbar palsy, and mental disorders ranging from mild confusion to coma. Death may occur. The motor and localizing signs of myelinolysis differ from the generalized encephalopathy that is caused by untreated hyponatremia. Experiments have duplicated the clinical and pathologic features of myelinolysis by rapidly reversing hyponatremia in animals. Myelinolysis is more likely to occur after the treatment of chronic rather than acute hyponatremia and is more likely to occur with a rapid rate of correction. The exact pathogenesis of myelinolysis has not been determined. Optimal management of hyponatremic patients involves weighing the risk for illness and death from untreated hyponatremia against the risk for myelinolysis due to correction of hyponatremia. Experiments in animals and clinical experience suggest that correction of chronic hyponatremia sh...Continue Reading

Citations

May 18, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yoon-Sik JoSang-Jun Na
Jul 27, 2001·Current Psychiatry Reports·D M Greenberg, J W Lee
Jun 23, 2010·Neurocritical Care·Andrew M NaidechKenji Muro
Dec 4, 2003·Parkinsonism & Related Disorders·Yasuhiko BabaMarlene M Normand
Aug 1, 1997·The Journal of Laboratory and Clinical Medicine·A SoupartG Decaux
Apr 5, 2000·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·A M Nayback
Oct 18, 2000·The Journal of Emergency Medicine·M J SagarinE S Nadel
Jun 12, 2001·The Journal of Emergency Medicine·R G KulkarniE S Nadel
Jan 25, 2000·The Journal of Emergency Medicine·D B SpeedyB Foley
Sep 6, 2002·Pediatric Neurology·Christian G LiljeMatthias Brandis
Nov 30, 2000·Anesthesiology Clinics of North America·D S Prough
May 24, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·C ChanT Harrington
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Eva-Maria Weiss-GuilletStephan M Jakob
Jan 26, 2007·Nature Clinical Practice. Nephrology·Sheldon ChenDaniel Batlle
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dominique GuyaderGayle P Orczyk
Oct 24, 1998·The New England Journal of Medicine·A J Behrman, R B Wilson
May 29, 2000·The New England Journal of Medicine·H J Adrogué, N E Madias
May 18, 2007·The New England Journal of Medicine·David H Ellison, Tomas Berl
Feb 21, 2003·Surgical Infections·C J ShieldsH P Redmond
Jul 22, 1998·The American Journal of the Medical Sciences·N A MoussaT M Yahya
May 10, 2000·Clinical Neuropharmacology·J FinstererM Stiskal
Oct 24, 2002·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·M SaltariniG Fabris
Nov 25, 2003·The Neurologist·Alejandro A Rabinstein, Eelco F M Wijdicks
Apr 22, 1999·Postgraduate Medical Journal·G Gill, G Leese
Mar 24, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ibrahim LasheenKamal A S Al-Shoumer
Jul 26, 2006·Neuroendocrinology·Akira SataKazue Takano
Jun 24, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Malvinder S Parmar
Feb 22, 2012·Neuropsychiatric Disease and Treatment·Paul SchneiderCheryl L Hurd
Sep 2, 2009·Drugs·Fedja A Rochling, Rowen K Zetterman
Jul 9, 2010·Future Cardiology·Ewout J Hoorn, Robert Zietse
Mar 4, 2014·Rinshō shinkeigaku = Clinical neurology·Toshiyuki Sakai, Hidekazu Tomimoto
May 19, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Stephanie A HowardUmberto De Girolami
Feb 27, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Goce SpasovskiUNKNOWN Hyponatraemia Guideline Development Group
May 12, 2006·Neurological Research·Suresh KumarS L Jaffe
Oct 12, 2010·Journal of Endocrinological Investigation·A PeriP Menè
Feb 27, 2014·European Journal of Endocrinology·Goce SpasovskiUNKNOWN Hyponatraemia Guideline Development Group
Jul 7, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·A ZiadiM A Samkaoui

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