Myeloablative treatments for multiple myeloma: update of a comparative study of different regimens used in patients from the Spanish registry for transplantation in multiple myeloma

Leukemia & Lymphoma
J J LahuertaSpanish Multiple Myeloma Group

Abstract

After a previous analysis that did not detect clear differences in the results of three conditioning regimens used for autologous stem cell transplantation (ASCT) in patients from the Spanish Registry for Transplant in Multiple Myeloma (MM), we have updated the registry, including a larger number of cases and a fourth conditioning regimen with a longer follow-up. We evaluate 472 MM patients treated with 200 mg/m2 melphalan (MEL200), 135 patients treated with 140 mg/m2 melphalan plus total body irradiation [(MEL140 + TBI)], 186 patients treated with 12 mg/kg busulphan plus 140 mg/m2 melphalan (BUMEL) and 28 patients treated with 14 mg/kg busulphan followed by cyclophosphamide 120 mg/kg (BUCY). There were no significant differences in respect to either transplant related death or haematological recovery, regardless of growth factor use, between the four conditioning programs. Nevertheless, hospitalization time with MEL200 was less than with BUMEL when growth factors were used (19+/-9 vs. 25+/-9 days, P = 0.009) and less than with MEL140 + TBI without growth factors (20+/-8 days vs. 27+/-9 days, P = 0.002). In patients with measurable disease at ASCT (non-complete remission [CR]), BUMEL achieved a 51% CR vs. 43%-31% in the other g...Continue Reading

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Citations

Jan 14, 2003·Hematological Oncology
Sep 28, 2002·Blood Reviews·Jean-Luc Harousseau, Michel Attal
Jan 25, 2003·British Journal of Haematology·Juan José LahuertaUNKNOWN Grupo Español de Síndromes Linfoproliferativos/Trasplante Autólogo de Médula Osea
Jul 29, 2010·Haematologica·Juan José LahuertaUNKNOWN Grupo Español de MM and Programa para el Estudio de la Terapéutica en Hemopatía Maligna Cooperative Study Groups
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Aug 24, 2007·Expert Opinion on Investigational Drugs·Pellegrino Musto, Fiorella D'Auria
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Aug 18, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Margarita BlanesJavier de la Rubia
Nov 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Enric CarrerasUNKNOWN Spanish Myeloma Group/PETHEMA
May 11, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tulio E RodriguezDavid H Vesole
Jul 20, 2005·Best Practice & Research. Clinical Haematology·Jean-Luc HarousseauHervé Avet-Loiseau

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