Myelodysplastic syndrome: an update on diagnosis and therapy.

Current Oncology Reports
Ahrin Koppel, Gary Schiller

Abstract

Myelodysplastic syndromes (MDS) are a diverse group of disorders characterized by disorderly and ineffective hematopoiesis. Patients suffer morbidity from associated cytopenias that result in an increased risk of infection, transfusion-dependent anemia, and bleeding. Despite the variable risk of transformation to acute leukemia, the majority of deaths are due to bone marrow failure. No truly effective treatment exists for MDS, and therapy usually focuses on reducing or preventing complications of the disease. Identification of potential cellular and molecular targets, such as epigenetic modification, has led to novel therapeutic approaches in recent years. An increasing number of diagnostic markers, prognostic parameters, and therapeutic strategies are available and becoming widely accepted.

References

Oct 1, 1989·Mayo Clinic Proceedings·A TefferiR V Pierre
Jun 1, 1982·British Journal of Haematology·J M BennettC Sultan
Aug 1, 1994·American Journal of Hematology·P BernasconiC Astori
Feb 1, 1996·British Journal of Haematology·A OrianiG Lambertenghi Deliliers
Oct 1, 1996·Australian and New Zealand Journal of Medicine·G ChandranD Coghlan
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N L HarrisC D Bloomfield
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lewis R SilvermanJames F Holland
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice B KornblithJimmie C Holland
Jan 21, 2003·Leukemia & Lymphoma·Muhammad Wasif SaifSteven D Gore
Jan 25, 2003·British Journal of Haematology·David BowenUNKNOWN UK MDS Guidelines Group
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Apr 2, 2004·Nature Reviews. Cancer·J Blake BartlettAngus G Dalgleish
Feb 11, 2005·The New England Journal of Medicine·Alan ListJerome B Zeldis
Jun 7, 2005·Cancer Letters·Anna D Panani, Charis Roussos
Jul 15, 2005·Seminars in Hematology·Hussain I Saba, Pierre W Wijermans
Oct 6, 2006·The New England Journal of Medicine·Alan ListUNKNOWN Myelodysplastic Syndrome-003 Study Investigators
Jul 3, 2007·Leukemia Research·Hans-Peter HornyPeter Valent
Nov 21, 2007·Hematology·Guillermo Garcia-Manero
Jan 19, 2008·Nature·Benjamin L EbertTodd R Golub

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Citations

Mar 14, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Nigel S Tan, Stephen W Hwang
Apr 1, 2008·Journal of Indian Association of Pediatric Surgeons·Senthilnathan RamasamyKrishnamohan Janardhanam
Sep 15, 2009·Leukemia Research·Yan DuEmanuela Taioli

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